Literature summary for 3.5.1.2 extracted from

Hu, W.; Zhang, C.; Wu, R.; Sun, Y.; Levine, A.; Feng, Z.
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function (2010), Proc. Natl. Acad. Sci. USA, 107, 7455-7460.

Search for more literature for 3.5.1.2

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	GLS2 expression is lost or greatly decreased in hepatocellular carcinomas and the overexpression of GLS2 greatly reduces tumor cell colony formation	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-glutamine + H2O	-	Homo sapiens	L-glutamate + NH3	-	?

Synonyms

Synonyms	Comment	Organism
GLS2	-	Homo sapiens
glutaminase 2	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	GLS2 expression is lost or greatly decreased in hepatocellular carcinomas and the overexpression of GLS2 greatly reduces tumor cell colony formation	additional information
Homo sapiens	p53 increases the GLS2 expression under both nonstressed and stressed conditions	up

General Information

General Information	Comment	Organism
physiological function	GLS2 identified as a previously uncharacterized p53 target gene to regulate cellular energy metabolism and antioxidant defense. GLS regulates cellular energy metabolism by increasing production of glutamate and 2-oxoglutarate, which in turn results in enhanced mitochondrial respiration and ATP generation. Furthemore GLS2 regulates antioxidant defense function in cells by increasing reduced glutathione levels and decreasing reactive oxygen spcies (ROS) levels, which in turn protects cells from oxidative stress	Homo sapiens

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Release 2023.1 (January 2023)