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Literature summary for 3.5.1.3 extracted from

  • Cooper, A.J.L.; Meister, A.
    The glutamine transaminase-omega-amidase pathway (1977), CRC Crit. Rev. Biochem., 4, 281-303.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
cytoplasm most of omega-amidase activity is present in cytoplasm Rattus norvegicus 5737
-
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
liver, high-speed sedimentation equilibrium and amino-acid analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxoglutaramate + H2O Mus musculus alpha-ketoglutaramate 2-oxoglutarate + NH3
-
?
2-oxoglutaramate + H2O Homo sapiens alpha-ketoglutaramate 2-oxoglutarate + NH3
-
?
2-oxoglutaramate + H2O Rattus norvegicus alpha-ketoglutaramate 2-oxoglutarate + NH3
-
?
2-oxoglutaramate + H2O Saccharomyces cerevisiae alpha-ketoglutaramate 2-oxoglutarate + NH3
-
?
2-oxoglutaramate + H2O Embryophyta alpha-ketoglutaramate 2-oxoglutarate + NH3
-
?
additional information Homo sapiens enzyme of glutamine-transaminase-omega-amidase pathway, role in degradation of glutamine ?
-
?
additional information Rattus norvegicus enzyme of glutamine-transaminase-omega-amidase pathway, role in degradation of glutamine ?
-
?
additional information Mus musculus second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway ?
-
?
additional information Homo sapiens second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway ?
-
?
additional information Rattus norvegicus second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway ?
-
?
additional information Rattus norvegicus glutamine-transaminase-omega-amidase pathway, metabolic role: utilization of glutamine, formation of ammonia, ammoniagenesis, and utilization of certain alpha-keto acids for synthesis of corresponding amino acids ?
-
?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Embryophyta
-
higher plants
-
Enterococcus faecalis
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
human
-
Lactuca sativa
-
lettuce
-
Mus musculus
-
-
-
Rattus norvegicus
-
contains isozymic forms, mitochondrial and cytosolic, of omega-amidase
-
Rattus norvegicus
-
liver, contains isozymic forms, mitochondrial and cytosolic, of omega-amidase
-
Saccharomyces cerevisiae
-
-
-
Spinacia oleracea
-
spinach
-

Purification (Commentary)

Purification (Comment) Organism
liver, cytoplasm Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH3 mechanism Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
cerebrospinal fluid
-
Homo sapiens
-
heart
-
Rattus norvegicus
-
kidney
-
Homo sapiens
-
kidney
-
Rattus norvegicus
-
kidney
-
Canis lupus familiaris
-
leaf
-
Spinacia oleracea
-
leaf
-
Lactuca sativa
-
liver
-
Mus musculus
-
liver
-
Rattus norvegicus
-
additional information
-
Mus musculus
-
additional information
-
Homo sapiens
-
additional information omega-amidase is widespread, detected in various rat organs Rattus norvegicus
-
muscle cardiac muscle and skeletal muscle Rattus norvegicus
-
Novikoff hepatoma cell
-
Rattus norvegicus
-
pancreas
-
Rattus norvegicus
-
spleen
-
Rattus norvegicus
-
testis
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutaramate + H2O sole substrate is the open-chain form of alpha-ketoglutaramate, not the cyclic form Rattus norvegicus 2-oxoglutarate + NH3
-
?
2-oxoglutaramate + H2O alpha-ketoglutaramate Mus musculus 2-oxoglutarate + NH3
-
?
2-oxoglutaramate + H2O alpha-ketoglutaramate Escherichia coli 2-oxoglutarate + NH3
-
?
2-oxoglutaramate + H2O alpha-ketoglutaramate Homo sapiens 2-oxoglutarate + NH3
-
?
2-oxoglutaramate + H2O alpha-ketoglutaramate Rattus norvegicus 2-oxoglutarate + NH3
-
?
2-oxoglutaramate + H2O alpha-ketoglutaramate Saccharomyces cerevisiae 2-oxoglutarate + NH3
-
?
2-oxoglutaramate + H2O alpha-ketoglutaramate Spinacia oleracea 2-oxoglutarate + NH3
-
?
2-oxoglutaramate + H2O alpha-ketoglutaramate Canis lupus familiaris 2-oxoglutarate + NH3
-
?
2-oxoglutaramate + H2O alpha-ketoglutaramate Enterococcus faecalis 2-oxoglutarate + NH3
-
?
2-oxoglutaramate + H2O alpha-ketoglutaramate Embryophyta 2-oxoglutarate + NH3
-
?
2-oxoglutaramate + H2O alpha-ketoglutaramate Lactuca sativa 2-oxoglutarate + NH3
-
?
2-oxosuccinamate + H2O alpha-ketosuccinamate Rattus norvegicus 2-oxosuccinate + NH3
-
?
2-oxosuccinamate + H2O open-chain form Rattus norvegicus 2-oxosuccinate + NH3
-
?
ethyl glutarate + methylamine methylamide formation Rattus norvegicus ?
-
?
ethyl succinate + methylamine methylamide formation Rattus norvegicus ?
-
?
gamma-ethyl 2-oxoglutarate + methylamine methylamide formation Rattus norvegicus ?
-
?
gamma-ethyl 2-oxoglutarate + methylamine gamma-ethyl alpha-ketoglutarate Rattus norvegicus ?
-
?
gamma-methyl 2-oxoglutarate + methylamine methylamide formation Rattus norvegicus ?
-
?
glutaramate + H2O
-
Rattus norvegicus glutarate + NH3
-
?
glutaramate + hydroxylamine hydroxaminolysis Rattus norvegicus glutaryl hydroxamate + NH3
-
?
methyl glutarate + methylamine methylamide formation Rattus norvegicus ?
-
?
methyl succinate + methylamine methylamide formation Rattus norvegicus ?
-
?
additional information no hydrolysis of asparagine and glutamine Rattus norvegicus ?
-
?
additional information catalyzes methylamide formation Rattus norvegicus ?
-
?
additional information catalyzes hydroxaminolysis and transamidation reactions with esters and amides Rattus norvegicus ?
-
?
additional information enzyme of glutamine-transaminase-omega-amidase pathway, role in degradation of glutamine Homo sapiens ?
-
?
additional information enzyme of glutamine-transaminase-omega-amidase pathway, role in degradation of glutamine Rattus norvegicus ?
-
?
additional information second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway Mus musculus ?
-
?
additional information second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway Homo sapiens ?
-
?
additional information second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway Rattus norvegicus ?
-
?
additional information glutamine-transaminase-omega-amidase pathway, metabolic role: utilization of glutamine, formation of ammonia, ammoniagenesis, and utilization of certain alpha-keto acids for synthesis of corresponding amino acids Rattus norvegicus ?
-
?
N-methyl-2-oxoglutaramate + H2O at a slow rate Rattus norvegicus 2-oxoglutarate + methylamine
-
?
N-methyl-2-oxoglutaramate + H2O N-methyl-alpha-ketoglutaramate Rattus norvegicus 2-oxoglutarate + methylamine
-
?
succinamate + H2O
-
Rattus norvegicus succinic acid + NH3
-
?
succinamate + hydroxylamine hydroxaminolysis Rattus norvegicus succinyl hydroxamate + NH3
-
r
succinyl hydroxamate + H2O
-
Rattus norvegicus succinate + hydroxylamine
-
r

Subunits

Subunits Comment Organism
dimer liver, 2 * 27000-28000, two subunits may be nonidentical, high-speed sedimentation equilibrium in the presence of 7 M guanidine hydrochloride or 7 M urea containing 0.1 M 2-mercaptoethanol Rattus norvegicus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
additional information
-
-
Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
-
Rattus norvegicus
6.5 9.5 broad pH-optimum, hydrolysis of alpha-ketosuccinamate Rattus norvegicus
9
-
hydrolysis of alpha-ketoglutaramate, sharp maximum Rattus norvegicus

pH Stability

pH Stability pH Stability Maximum Comment Organism
additional information
-
-
Rattus norvegicus