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Literature summary for 3.5.1.5 extracted from
- The synthesis, structure and activity evaluation of pyrogallol and catechol derivatives as Helicobacter pylori urease inhibitors (2010), Eur. J. Med. Chem., 45, 5064-5070.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-[2-(3,4-dimethoxyphenyl)ethyl]phenol | - |
Helicobacter pylori |  |
| 4-butylbenzene-1,2,3-triol | - |
Helicobacter pylori | |
| 4-butylbenzene-1,2-diol | - |
Helicobacter pylori | |
| 4-decylbenzene-1,2,3-triol | - |
Helicobacter pylori | |
| 4-dodecylbenzene-1,2,3-triol | - |
Helicobacter pylori | |
| 4-ethylbenzene-1,2,3-triol | - |
Helicobacter pylori | |
| 4-ethylbenzene-1,2-diol | - |
Helicobacter pylori | |
| 4-hexylbenzene-1,2,3-triol | - |
Helicobacter pylori | |
| 4-hexylbenzene-1,2-diol | - |
Helicobacter pylori | |
| 4-octylbenzene-1,2,3-triol | - |
Helicobacter pylori | |
| 4-octylbenzene-1,2-diol | - |
Helicobacter pylori | |
| 4-tetradecylbenzene-1,2,3-triol | - |
Helicobacter pylori | |
| 4-[2-(3,4-diethoxyphenyl)ethyl]benzene-1,2,3-triol | - |
Helicobacter pylori | |
| 4-[2-(3,4-dimethoxyphenyl)ethyl]benzene-1,2,3-triol | - |
Helicobacter pylori | |
| 4-[2-(3,4-dimethoxyphenyl)ethyl]benzene-1,2-diol | - |
Helicobacter pylori | |
| 4-[2-(3,4-dimethoxyphenyl)ethyl]phenol | - |
Helicobacter pylori | |
| 4-[2-(3-bromophenyl)ethyl]benzene-1,2,3-triol | - |
Helicobacter pylori | |
| 4-[2-(3-bromophenyl)ethyl]benzene-1,2-diol | - |
Helicobacter pylori | |
| 4-[2-(3-chlorophenyl)ethyl]-1,2-dimethoxybenzene | - |
Helicobacter pylori | |
| 4-[2-(3-chlorophenyl)ethyl]benzene-1,2,3-triol | - |
Helicobacter pylori | |
| 4-[2-(3-chlorophenyl)ethyl]benzene-1,2-diol | - |
Helicobacter pylori | |
| 4-[2-(4-bromophenyl)ethyl]benzene-1,2,3-triol | - |
Helicobacter pylori | |
| 4-[2-(4-chlorophenyl)ethyl]-1,2-dimethoxybenzene | - |
Helicobacter pylori | |
| 4-[2-(4-chlorophenyl)ethyl]benzene-1,2,3-triol | - |
Helicobacter pylori | |
| 4-[2-(4-chlorophenyl)ethyl]benzene-1,2-diol | - |
Helicobacter pylori | |
| 4-[2-(4-fluorophenyl)ethyl]benzene-1,2,3-triol | - |
Helicobacter pylori | |
| 4-[2-(4-fluorophenyl)ethyl]benzene-1,2-diol | - |
Helicobacter pylori | |
| 4-[2-(4-hydroxyphenyl)ethyl]benzene-1,2,3-triol | - |
Helicobacter pylori | |
| 4-[2-(4-hydroxyphenyl)ethyl]benzene-1,2-diol | - |
Helicobacter pylori | |
| N-hydroxyacetamide | - |
Helicobacter pylori | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Helicobacter pylori | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| urea + H2O | - |
Helicobacter pylori | CO2 + 2 NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| urease | - |
Helicobacter pylori |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0015 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(4-hydroxyphenyl)ethyl]benzene-1,2-diol | |
| 0.0049 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-ethylbenzene-1,2-diol | |
| 0.0062 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(4-fluorophenyl)ethyl]benzene-1,2-diol | |
| 0.0079 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-butylbenzene-1,2-diol | |
| 0.0083 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(4-chlorophenyl)ethyl]benzene-1,2-diol | |
| 0.0123 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-hexylbenzene-1,2-diol | |
| 0.0157 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(3-chlorophenyl)ethyl]benzene-1,2-diol | |
| 0.0169 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(3-bromophenyl)ethyl]benzene-1,2-diol | |
| 0.0172 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | N-hydroxyacetamide | |
| 0.0227 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(3,4-dimethoxyphenyl)ethyl]benzene-1,2-diol | |
| 0.032 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(4-hydroxyphenyl)ethyl]benzene-1,2,3-triol | |
| 0.034 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-ethylbenzene-1,2,3-triol | |
| 0.043 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(4-fluorophenyl)ethyl]benzene-1,2,3-triol | |
| 0.047 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(4-chlorophenyl)ethyl]benzene-1,2,3-triol | |
| 0.048 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(4-bromophenyl)ethyl]benzene-1,2,3-triol | |
| 0.05 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(3-chlorophenyl)ethyl]benzene-1,2,3-triol | |
| 0.052 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(3-bromophenyl)ethyl]benzene-1,2,3-triol | |
| 0.058 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-octylbenzene-1,2-diol | |
| 0.069 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(3,4-diethoxyphenyl)ethyl]benzene-1,2,3-triol | |
| 0.071 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(3,4-dimethoxyphenyl)ethyl]benzene-1,2,3-triol | |
| 0.079 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-butylbenzene-1,2,3-triol | |
| 0.091 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-hexylbenzene-1,2,3-triol | |
| 0.103 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-octylbenzene-1,2,3-triol | |
| 0.124 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-decylbenzene-1,2,3-triol | |
| 0.168 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-dodecylbenzene-1,2,3-triol | |
| 0.204 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(3,4-dimethoxyphenyl)ethyl]phenol | |
| 0.227 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 2-[2-(3,4-dimethoxyphenyl)ethyl]phenol | |
| 0.235 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(3-chlorophenyl)ethyl]-1,2-dimethoxybenzene | |
| 0.25 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-tetradecylbenzene-1,2,3-triol | |
| 0.254 | - |
cell free urease preparation, pH not specified in the publication, temperature not specified in the publication | Helicobacter pylori | 4-[2-(4-chlorophenyl)ethyl]-1,2-dimethoxybenzene | |
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