Application | Comment | Organism |
---|---|---|
drug development | urease is considered a first line target for drug development and vaccination against Helicobacter pylori infection | Helicobacter pylori |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Hpn protein | synthesis and purifcation of the 7 kDa protein, the synthetic nickel-binding histidine-rich protein designated Hpn is capable of abrogating urease activity of live Heicobacter pylori in liquid cultures due to inhibition of nickel uptake into cells | Helicobacter pylori |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ni2+ | the catalytic activity of urease is mediated by nickel ions | Helicobacter pylori |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
urea + H2O | Helicobacter pylori | - |
CO2 + 2 NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Helicobacter pylori | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
urea + H2O | - |
Helicobacter pylori | CO2 + 2 NH3 | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | neutralization of acid by ammonia is essential for gastric Helicobacter pylori colonization | Helicobacter pylori |