Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-[(2-acetylanilino)methylidene]-8-methyl-2H-pyrido[1,2-a]-pyrimidine-2,4-dione | 54% inhibition at 0.01 mM | Canavalia ensiformis | |
3-[(2-fluoroanilino)methylidene]-8-methyl-2H-pyrido[1,2-a]-pyrimidine-2,4-dione | 44% inhibition at 0.01 mM | Canavalia ensiformis | |
3-[(3-acetylanilino)methylidene]-8-methyl-2H-pyrido[1,2-a]-pyrimidine-2,4-dione | 28% inhibition at 0.01 mM | Canavalia ensiformis | |
3-[(3-fluoroanilino)methylidene]-8-methyl-2H-pyrido[1,2-a]-pyrimidine-2,4-dione | 3% inhibition at 0.01 mM | Canavalia ensiformis | |
3-[(4-acetylanilino)methylidene]-8-methyl-2H-pyrido[1,2-a]pyrimidine-2,4-dione | 5% inhibition at 0.01 mM | Canavalia ensiformis | |
3-[(4-fluoroanilino)methylidene]-8-methyl-2H-pyrido[1,2-a]pyrimidine-2,4-dione | 21% inhibition at 0.01 mM | Canavalia ensiformis | |
3-[(mesitylamino)methylidene]-8-methyl-2H-pyrido[1,2-a]pyrimidine-2,4-dione | - |
Canavalia ensiformis | |
4-bromo-N'-[[8-methyl-2,4-dioxo-2H-pyrido[1,2-a]pyrimidin-3(4H)-ylidene]methyl]benzohydrazide | 23% inhibition at 0.01 mM | Canavalia ensiformis | |
4-chloro-N'-[[8-methyl-2,4-dioxo-2H-pyrido[1,2-a]pyrimidin-3(4H)-ylidene]methyl]benzohydrazide | 14% inhibition at 0.01 mM | Canavalia ensiformis | |
4-hydroxy-N'-[[8-methyl-2,4-dioxo-2H-pyrido[1,2-a]pyrimidin-3(4H)-ylidene]methyl]benzohydrazide | 22% inhibition at 0.01 mM | Canavalia ensiformis | |
4-nitro-N'-[[8-methyl-2,4-dioxo-2H-pyrido[1,2-a]pyrimidin-3(4H)-ylidene]methyl] benzohydrazide | 60% inhibition at 0.01 mM | Canavalia ensiformis | |
8-methyl-2H-pyrido[1,2-a]pyrimidine-2,4(3H)-dione | 26% inhibition at 0.01 mM | Canavalia ensiformis | |
8-methyl-3-[(2-sulfanylanilino)methylidene]-2H-pyrido[1,2-a]pyrimidine-2,4-dione | 73% inhibition at 0.01 mM | Canavalia ensiformis | |
8-methyl-3-[[(4-methyl-2-pyridinyl)amino]methylidene]-2Hpyrido[1,2-]pyrimidine-2,4-dione | 20% inhibition at 0.01 mM | Canavalia ensiformis | |
8-methyl-3-[[(5-methyl-2-pyridinyl)amino] methylidene]-2H-pyrido[1,2-]pyrimidine-2,4-dione | 48% inhibition at 0.01 mM | Canavalia ensiformis | |
8-methyl-3-[[(5-nitro-2-pyridinyl)amino] methylidene]-2H-pyrido[1,2-a]pyrimidine-2,4-dione | 36% inhibition at 0.01 mM | Canavalia ensiformis | |
additional information | synthesis, characterization, and urease inhibition of 5-substituted-8-methyl-2H-pyrido[1,2-a]pyrimidine-2,4(3H)-diones, anilines, amino pyridines and hydrazides derivatives, detailed overview. No inhibition by 5 | Canavalia ensiformis | |
N'-[[8-methyl-2,4-dioxo-2H-pyrido[1,2-a]pyrimidin-3(4H)-ylidene]methyl]-benzo-hydrazide | 13% inhibition at 0.01 mM | Canavalia ensiformis | |
Thiourea | 21% inhibition at 0.01 mM | Canavalia ensiformis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
urea + H2O | Canavalia ensiformis | - |
CO2 + 2 NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canavalia ensiformis | P07374 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
urea + H2O | - |
Canavalia ensiformis | CO2 + 2 NH3 | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Canavalia ensiformis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.021 | - |
pH not specified in the publication, 25°C | Canavalia ensiformis | 8-methyl-2H-pyrido[1,2-a]pyrimidine-2,4(3H)-dione |