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Literature summary for 3.5.1.9 extracted from
- Isolation and molecular properties of formamidase from rat liver cytoplasm (1973), Hoppe-Seyler's Z. Physiol. Chem., 354, 1583-1590.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bis(4-nitrophenyl)phosphate | slight inhibition at 1 mM after 30 min preincubation | Rattus sp. |  |
| Hg2+ | complete inhibition at 1 mM | Rattus sp. | |
| O,O-Diethyl-O-(4-nitrophenyl)phosphate | E600, complete inhibition at 1 mM | Rattus sp. | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus sp. | 5737 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 34700 | - |
gel filtration | Rattus sp. |
| 35500 | - |
1 * 35500, SDS-PAGE | Rattus sp. |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-formyl-L-kynurenine + H2O | Rattus sp. | - |
L-kynurenine + formate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus sp. | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| to homogeneity, chromatography steps, isoelectric focusing | Rattus sp. |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus sp. | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 303 | - |
- |
Rattus sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-formyl-L-kynurenine + H2O | - |
Rattus sp. | L-kynurenine + formate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 35500, SDS-PAGE | Rattus sp. |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
- |
Rattus sp. |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 35 | 60 | activity constant within | Rattus sp. |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
sharp decline of activity | Rattus sp. |
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