Literature summary for 3.5.2.6 extracted from

Kuzin, A.P.; Nukaga, M.; Nukaga, Y.; Hujer, A.; Bonomo, R.A.; Knox, J.R.
Inhibition of the SHV-1 beta-lactamase by sulfones: crystallographic observation of two reaction intermediates with tazobactam (2001), Biochemistry, 40, 1861-1866.

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Inhibitors

Inhibitors	Comment	Organism	Structure
clavulanic acid	-	Klebsiella pneumoniae
additional information	mechanism-based inhibition mechanism	Klebsiella pneumoniae
Sulbactam	-	Klebsiella pneumoniae
tazobactam	sulfone inhibitor, acyclic form is covalently bound to ctalytic Ser70 side chain	Klebsiella pneumoniae
tazobactam fragment	five-atom vinyl carboxylic acid fragment of tazobactam, bonded to Ser130	Klebsiella pneumoniae

Organism

Organism	UniProt	Comment	Textmining
Klebsiella pneumoniae	P0AD64	class A enzyme SHV-1	-
Klebsiella pneumoniae 15571	P0AD64	class A enzyme SHV-1	-

Synonyms

Synonyms	Comment	Organism
SHV-1	-	Klebsiella pneumoniae

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Release 2023.1 (January 2023)