Literature summary for 3.5.2.6 extracted from

Chen, Y.; Cheng, J.; Wang, Q.; Ye, Y.; Li, J.; Zhang, X.
ACT-3, a novel plasmid-encoded class C beta -lactamase in a Klebsiella pneumoniae isolate from China (2009), Int. J. Antimicrob. Agents, 33, 95-96.

Search for more literature for 3.5.2.6

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.026	-	penicillin G	-	Klebsiella pneumoniae
0.027	-	cefotaxime	-	Klebsiella pneumoniae
0.043	-	cefuroxime	-	Klebsiella pneumoniae
0.046	-	cefoxitin	-	Klebsiella pneumoniae
0.06	-	cefalothin	-	Klebsiella pneumoniae
0.112	-	ceftazidime	-	Klebsiella pneumoniae

Organism

Organism	UniProt	Comment	Textmining
Klebsiella pneumoniae	A1EGT8	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cefalotin + H2O	-	Klebsiella pneumoniae	(2R)-5-[(acetyloxy)methyl]-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid	-	?
cefotaxime + H2O	-	Klebsiella pneumoniae	(2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid	-	?
cefoxitin + H2O	-	Klebsiella pneumoniae	(2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid	-	?
ceftazidime + H2O	-	Klebsiella pneumoniae	(2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate	-	?
cefuroxime + H2O	-	Klebsiella pneumoniae	(2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid	-	?
penicillin G + H2O	-	Klebsiella pneumoniae	(2R,4S)-2-[(R)-carboxy[(phenylacetyl)amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid	-	?

Synonyms

Synonyms	Comment	Organism
ACT-3	plasmid-encoded class C beta-lactamase	Klebsiella pneumoniae
AmpC-type beta-lactamase	-	Klebsiella pneumoniae
class C beta-lactamase	-	Klebsiella pneumoniae

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Release 2023.1 (January 2023)