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Literature summary for 3.5.2.6 extracted from

  • Santella, G.; Docquier, J.D.; Gutkind, G.; Rossolini, G.M.; Radice, M.
    Purification and biochemical characterization of IMP-13 metallo-beta-lactamase (2011), Antimicrob. Agents Chemother., 55, 399-401.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.2.6

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0008
-
 ertapenem pH 7.5, 37°C Pseudomonas aeruginosa
0.001
-
 cefuroxime pH 7.5, 37°C Pseudomonas aeruginosa
0.008
-
 cefepime pH 7.5, 37°C Pseudomonas aeruginosa
0.01
-
 meropenem pH 7.5, 37°C Pseudomonas aeruginosa
0.012
-
 cefoxitin pH 7.5, 37°C Pseudomonas aeruginosa
0.015
-
 ceftazidime pH 7.5, 37°C Pseudomonas aeruginosa
0.021
-
 cefotaxime pH 7.5, 37°C Pseudomonas aeruginosa
0.031
-
 cephalotin pH 7.5, 37°C Pseudomonas aeruginosa
0.049
-
 Imipenem pH 7.5, 37°C Pseudomonas aeruginosa
0.13
-
 ticarcillin pH 7.5, 37°C Pseudomonas aeruginosa
0.15
-
 piperacillin pH 7.5, 37°C Pseudomonas aeruginosa
0.21
-
 ampicillin pH 7.5, 37°C Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q7WYA8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ampicillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
cefepime + H2O
-
 Pseudomonas aeruginosa (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
cefotaxime + H2O
-
 Pseudomonas aeruginosa (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
cefoxitin + H2O
-
 Pseudomonas aeruginosa (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
ceftazidime + H2O
-
 Pseudomonas aeruginosa (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino](carboxy)methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
cefuroxime + H2O
-
 Pseudomonas aeruginosa (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
cephalotin + H2O
-
 Pseudomonas aeruginosa (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
ertapenem + H2O
-
 Pseudomonas aeruginosa (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-([(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl)-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
imipenem + H2O
-
 Pseudomonas aeruginosa (5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
meropenem + H2O
-
 Pseudomonas aeruginosa (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-[[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
piperacillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
ticarcillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-[(R)-carboxy[[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Synonyms

Synonyms Comment Organism
IMP-13
-
 Pseudomonas aeruginosa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.4
-
 meropenem pH 7.5, 37°C Pseudomonas aeruginosa
1.8
-
 ertapenem pH 7.5, 37°C Pseudomonas aeruginosa
9
-
 ceftazidime pH 7.5, 37°C Pseudomonas aeruginosa
12
-
 cefepime pH 7.5, 37°C Pseudomonas aeruginosa
23
-
 cefuroxime pH 7.5, 37°C Pseudomonas aeruginosa
25
-
 cephalotin pH 7.5, 37°C Pseudomonas aeruginosa
33
-
 cefotaxime pH 7.5, 37°C Pseudomonas aeruginosa
35
-
 cefoxitin pH 7.5, 37°C Pseudomonas aeruginosa
82
-
 ampicillin pH 7.5, 37°C Pseudomonas aeruginosa
120
-
 Imipenem pH 7.5, 37°C Pseudomonas aeruginosa
220
-
 ticarcillin pH 7.5, 37°C Pseudomonas aeruginosa
280
-
 piperacillin pH 7.5, 37°C Pseudomonas aeruginosa

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
140
-
 meropenem pH 7.5, 37°C Pseudomonas aeruginosa
380
-
 ampicillin pH 7.5, 37°C Pseudomonas aeruginosa
600
-
 ceftazidime pH 7.5, 37°C Pseudomonas aeruginosa
810
-
 cephalotin pH 7.5, 37°C Pseudomonas aeruginosa
1500
-
 cefepime pH 7.5, 37°C Pseudomonas aeruginosa
1600
-
 cefotaxime pH 7.5, 37°C Pseudomonas aeruginosa
1800
-
 ticarcillin pH 7.5, 37°C Pseudomonas aeruginosa
1900
-
 piperacillin pH 7.5, 37°C Pseudomonas aeruginosa
2200
-
 ertapenem pH 7.5, 37°C Pseudomonas aeruginosa
2300
-
 cefuroxime pH 7.5, 37°C Pseudomonas aeruginosa
2500
-
 Imipenem pH 7.5, 37°C Pseudomonas aeruginosa
2900
-
 cefoxitin pH 7.5, 37°C Pseudomonas aeruginosa