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Literature summary for 3.5.2.6 extracted from

  • Rezai, M.S.; Salehifar, E.; Rafiei, A.; Langaee, T.; Rafati, M.; Shafahi, K.; Eslami, G.
    Characterization of multidrug resistant extended-spectrum beta-lactamase-producing Escherichia coli among uropathogens of pediatrics in north of Iran (2015), BioMed Res. Int., 2015, 309478 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.2.6

Cloned(Commentary)

Cloned (Comment) Organism
diverse multidrug resistant extended-spectrum beta-lactamase-producing Escherichia coli strains among uropathogens of pediatrics in north of Iran are isolated and tested by PCR for the presence or absence of CTX, TEM, SHV, GES, and VEB beta-lactamase genes, genotyping Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amikacin + H2O Escherichia coli
-
 ?
-
 ?
carbapenem + H2O Escherichia coli
-
 [(2R)-2,3-dihydro-1H-pyrrol-2-yl]acetic acid
-
 ?
cefepime + H2O Escherichia coli
-
 (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
cefixime + H2O Escherichia coli
-
 ?
-
 ?
cefotaxime + H2O Escherichia coli
-
 (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
ceftazidime + H2O Escherichia coli
-
 ?
-
 ?
ceftizoxime + H2O Escherichia coli
-
 ?
-
 ?
ceftriaxone + H2O Escherichia coli
-
 ?
-
 ?
ciprofloxacin + H2O Escherichia coli
-
 ?
-
 ?
colistin + H2O Escherichia coli
-
 ?
-
 ?
gentamicin + H2O Escherichia coli
-
 ?
-
 ?
imipenem + H2O Escherichia coli
-
 (5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
meropenem + H2O Escherichia coli
-
 (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-[[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
additional information Escherichia coli substrate specificity in vivo with different enzymes genotypes, overview ?
-
-
piperacillin + H2O Escherichia coli
-
 (2R,4S)-2-[(R)-carboxy([(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-phenylacetyl]amino)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 multidrug resistant extended-spectrum beta-lactamase-producing Escherichia coli among uropathogens of pediatrics in north of Iran
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amikacin + H2O
-
 Escherichia coli ?
-
 ?
carbapenem + H2O
-
 Escherichia coli [(2R)-2,3-dihydro-1H-pyrrol-2-yl]acetic acid
-
 ?
cefepime + H2O
-
 Escherichia coli (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
cefixime + H2O
-
 Escherichia coli ?
-
 ?
cefotaxime + H2O
-
 Escherichia coli (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
ceftazidime + H2O
-
 Escherichia coli ?
-
 ?
ceftizoxime + H2O
-
 Escherichia coli ?
-
 ?
ceftriaxone + H2O
-
 Escherichia coli ?
-
 ?
ciprofloxacin + H2O
-
 Escherichia coli ?
-
 ?
colistin + H2O
-
 Escherichia coli ?
-
 ?
gentamicin + H2O
-
 Escherichia coli ?
-
 ?
imipenem + H2O
-
 Escherichia coli (5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
meropenem + H2O
-
 Escherichia coli (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-[[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
additional information substrate specificity in vivo with different enzymes genotypes, overview Escherichia coli ?
-
-
piperacillin + H2O
-
 Escherichia coli (2R,4S)-2-[(R)-carboxy([(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-phenylacetyl]amino)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

General Information

General Information Comment Organism
additional information Escherichia coli remains as one of the most important bacteria causing infections in pediatrics and producing extended-spectrum beta-lactamases (ESBLs) making them resistant to beta-lactam antibiotics. Multidrug resistant extended-spectrum beta-lactamase-producing Escherichia coli strains among uropathogens of pediatrics in north of Iran are isolated and tested by PCR for the presence or absence of CTX, TEM, SHV, GES, and VEB beta-lactamase genes. Genotyping reveals that the TEM gene is the most prevalent (49%) followed by SHV (44%), CTX (28%), VEB (8%), and GES (0%) genes. The ESBL-producing Escherichia coli isolates are susceptible to carbapenems (66%) and amikacin (58%) and show high resistance to cefixime (99%), colistin (82%), and ciprofloxacin (76%). Carbapenems are the most effective antibiotics against ESBl-producing Escherichia coli in urinary tract infection in north of Iran Escherichia coli