Literature summary for 3.5.2.6 extracted from

White, D.S.; Choy, C.J.; Moural, T.W.; Martin, S.E.; Wang, J.; Gargaro, S.; Kang, C.; Berkman, C.E.
Bis(benzoyl) phosphate inactivators of beta-lactamase C from Mtb (2019), Bioorg. Med. Chem. Lett., 29, 2116-2118 .

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Application

Application	Comment	Organism
drug development	enzyme BlaC is a rational enzyme target for therapeutic agents in treatment of tuberculosis caused by Mycobacterium tuberculosis	Mycobacterium tuberculosis

Inhibitors

Inhibitors	Comment	Organism	Structure
bis(3,4-dichlorobenzoyl) phosphate	-	Mycobacterium tuberculosis
bis(4-chlorobenzoyl) phosphate	-	Mycobacterium tuberculosis
bis(4-cyanobenzoyl) phosphate	-	Mycobacterium tuberculosis
bis(4-fluorobenzoyl) phosphate	-	Mycobacterium tuberculosis
bis(4-methoxybenzoyl)	-	Mycobacterium tuberculosis
bis(4-methylbenzoyl) phosphate	-	Mycobacterium tuberculosis
bis(4-nitrobenzoyl) phosphate	-	Mycobacterium tuberculosis
bis[4-(trifluoromethyl)benzoyl] phosphate	-	Mycobacterium tuberculosis
di([1,1'-biphenyl]-4-carbonyl) phosphate	-	Mycobacterium tuberculosis
dibenzoyl phosphate	-	Mycobacterium tuberculosis
additional information	synthesis and structure-activity-relationship data for the first-generation library of bis(benzoyl)phosphates as enzyme inhibitors, overview. Phosphorylated Ser70 in BlaC following inactivation by dibenzoyl phosphate	Mycobacterium tuberculosis

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell surface	the class A beta-lactamase BlaC is a cell surface expressed serine hydrolase	Mycobacterium tuberculosis	9986	-

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WKD3	-	-
Mycobacterium tuberculosis ATCC 25618	P9WKD3	-	-
Mycobacterium tuberculosis H37Rv	P9WKD3	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	phosphorylated Ser70 in BlaC following inactivation by dibenzoyl phosphate	Mycobacterium tuberculosis

Synonyms

Synonyms	Comment	Organism
BlaC	-	Mycobacterium tuberculosis
class A beta-lactamase	-	Mycobacterium tuberculosis

General Information

General Information	Comment	Organism
malfunction	inactivation of the cell surface-expressed serine hydrolase and class A beta-lactamase BlaC in Mycobacterium tuberculosis (Mtb) causes increased susceptibility to beta-lactam antibiotics	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)