Inhibitors | Comment | Organism | Structure |
---|---|---|---|
iodoacetamide | - |
Rattus norvegicus | |
L-2-imidazolidone-4-carboxylate | - |
Mus musculus | |
L-2-imidazolidone-4-carboxylate | - |
Rattus norvegicus | |
L-dihydroorotic acid | - |
Mus musculus | |
L-dihydroorotic acid | - |
Rattus norvegicus | |
N-ethylmaleimide | - |
Rattus norvegicus | |
p-hydroxymercuribenzoate | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.05 | - |
5-oxoproline | - |
Rattus norvegicus | |
0.17 | - |
ATP | - |
Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | requires monovalent cation, K+ or NH4+ | Rattus norvegicus | |
Mg2+ | - |
Rattus norvegicus | |
Mn2+ | - |
Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
325000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-oxo-L-proline + H2O + ATP | Mus musculus | - |
L-glutamate + ADP + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | Rattus norvegicus | - |
L-glutamate + ADP + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | Sus scrofa | - |
L-glutamate + ADP + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | Bos taurus | - |
L-glutamate + ADP + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | Oryctolagus cuniculus | - |
L-glutamate + ADP + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | Ovis aries | - |
L-glutamate + ADP + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | Canis lupus familiaris | - |
L-glutamate + ADP + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | Felis catus | - |
L-glutamate + ADP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
cow | - |
Canis lupus familiaris | - |
dog | - |
Felis catus | - |
cat | - |
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
rabbit | - |
Ovis aries | - |
sheep | - |
Rattus norvegicus | - |
- |
- |
Rattus norvegicus | - |
rat | - |
Rattus norvegicus Sprague-Dawley | - |
- |
- |
Sus scrofa | - |
pig | - |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Rattus norvegicus | - |
brain | - |
Sus scrofa | - |
brain | - |
Oryctolagus cuniculus | - |
ciliary body | - |
Rattus norvegicus | - |
ciliary body | - |
Oryctolagus cuniculus | - |
kidney | - |
Mus musculus | - |
kidney | - |
Rattus norvegicus | - |
kidney | - |
Sus scrofa | - |
kidney | - |
Bos taurus | - |
kidney | - |
Oryctolagus cuniculus | - |
kidney | - |
Ovis aries | - |
kidney | - |
Canis lupus familiaris | - |
kidney | - |
Felis catus | - |
liver | - |
Mus musculus | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Sus scrofa | - |
liver | - |
Oryctolagus cuniculus | - |
lung | - |
Rattus norvegicus | - |
ovary | - |
Oryctolagus cuniculus | - |
spleen | - |
Rattus norvegicus | - |
spleen | - |
Oryctolagus cuniculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.88 | - |
- |
Rattus norvegicus |
Storage Stability | Organism |
---|---|
4°C, 30 mM Tris-HCl buffer pH 7.8, 10 mM potassium chloride, 1 mM MgCl2, 5 mM 5-oxoproline, activity decreases to about 60% of its initial value after 2 days, 42% after 4 days and 40% after 5-6 days, addition of dithiothreitol leads to 104% of initial activity | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-imidazolidone-4-carboxylate + ATP + H2O | - |
Rattus norvegicus | 2-imidazolidone + ADP + phosphate | - |
? | |
2-piperidone-6-carboxylate + ATP + H2O | - |
Rattus norvegicus | 2-aminoadipate + phosphate + ADP | - |
? | |
3-oxy-5-oxoproline + H2O | - |
Rattus norvegicus | 3-oxyglutamate + phosphate | - |
? | |
4-oxy-5-oxoproline + H2O | - |
Rattus norvegicus | 4-oxyglutamate + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | - |
Mus musculus | L-glutamate + ADP + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | - |
Rattus norvegicus | L-glutamate + ADP + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | - |
Sus scrofa | L-glutamate + ADP + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | - |
Bos taurus | L-glutamate + ADP + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | - |
Oryctolagus cuniculus | L-glutamate + ADP + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | - |
Ovis aries | L-glutamate + ADP + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | - |
Canis lupus familiaris | L-glutamate + ADP + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | - |
Felis catus | L-glutamate + ADP + phosphate | - |
? | |
ATP + H2O | - |
Rattus norvegicus | ? | - |
? | |
ATP + H2O | - |
Rattus norvegicus Sprague-Dawley | ? | - |
? | |
dATP + H2O | - |
Rattus norvegicus | ? | - |
? | |
dATP + H2O | - |
Rattus norvegicus Sprague-Dawley | ? | - |
? | |
GTP + H2O | - |
Rattus norvegicus | ? | - |
? | |
GTP + H2O | - |
Rattus norvegicus Sprague-Dawley | ? | - |
? | |
ITP + H2O | - |
Rattus norvegicus | ? | - |
? | |
ITP + H2O | - |
Rattus norvegicus Sprague-Dawley | ? | - |
? | |
additional information | L-proline, 2-pyrrolidone, N-methyl-5-oxo-L-proline, DL-piperidine-2-carboxylic acid and cyclohexanone-3-carboxylic acid are no substrates | Rattus norvegicus | ? | - |
? | |
additional information | L-proline, 2-pyrrolidone, N-methyl-5-oxo-L-proline, DL-piperidine-2-carboxylic acid and cyclohexanone-3-carboxylic acid are no substrates | Rattus norvegicus Sprague-Dawley | ? | - |
? | |
UTP + H2O | - |
Rattus norvegicus | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
second pH optimum at pH 9.7 | Rattus norvegicus |
9.7 | - |
second pH optimum at pH 7.0 | Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.5 | 11.2 | - |
Rattus norvegicus |