Protein Variants | Comment | Organism |
---|---|---|
H101N | 60% of wild-type activity, unaltered Km for arginine and Ki for lysine compared to the wild-type enzyme | Homo sapiens |
H126N | 82% of wild-type activity, unaltered Km for arginine and Ki for lysine compared to the wild-type enzyme | Homo sapiens |
H141F | activation by Mn2+ | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diethyl dicarbonate | causes a loss in ability of Mn2+ to reactivate inactive subunits of wild-type and mutant enzyme H141F, effect is reversed by hydroxylamine | Homo sapiens | |
EDTA | - |
Homo sapiens | |
lysine | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | activates, role of weakly and tightly bound metal ions in wild-type and mutant enzymes, metal content, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-arginine + H2O | - |
Homo sapiens | L-ornithine + urea | - |
? |