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Literature summary for 3.5.3.1 extracted from

  • Colleluori, D.M.; Ash, D.E.
    Classical and slow-binding inhibitors of human type II arginase (2001), Biochemistry, 40, 9356-9362.
    View publication on PubMed
Search for more literature for 3.5.3.1

Application

Application Comment Organism
medicine enzyme is a target for inhibitors used in therapeutic treatment of smooth muscle disorders, such as erectile dysfunction Homo sapiens
pharmacology enzyme is a target for inhibitor design based on arginine analogues with uncharged, tetrahedral functional groups Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(S)-(2-boronoethyl)-L-cysteine boronic acid-based transition state analogue, classical competitive inhibition at pH 7.5, slow-binding inhibition at pH 9.5 Homo sapiens
2(S)-amino-6-boronohexanoic acid boronic acid-based transition state analogue, classical competitive inhibition at pH 7.5, slow-binding inhibition at pH 9.5 Homo sapiens
agmatine
-
 Homo sapiens
L-argininamide
-
 Homo sapiens
L-argininic acid
-
 Homo sapiens
L-canavanine
-
 Homo sapiens
L-homoarginine
-
 Homo sapiens
L-N5-(1-iminoethyl)-ornithine
-
 Homo sapiens
L-N6-(1-iminoethyl)-lysine
-
 Homo sapiens
L-thiocitrulline
-
 Homo sapiens
Nomega-amino-L-arginine
-
 Homo sapiens
Nomega-hydroxy-L-arginine competitive, reaction intermediate Homo sapiens
Nomega-hydroxy-nor-L-arginine competitive, reaction intermediate analogue Homo sapiens
Nomega-Nitro-L-arginine
-
 Homo sapiens
S-(2-aminoethyl)isothiourea
-
 Homo sapiens
S-(3-aminopropyl)isothiourea
-
 Homo sapiens
S-methyl-L-thiocitrulline
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine + H2O Homo sapiens enzyme is involved in regulation of nitric oxide biosynthesis by modulating arginine availability for nitric oxide synthase L-ornithine + urea
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme type II
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine + H2O enzyme is involved in regulation of nitric oxide biosynthesis by modulating arginine availability for nitric oxide synthase Homo sapiens L-ornithine + urea
-
 ?
L-arginine + H2O reaction intermediate is Nomega-hydroxy-L-arginine Homo sapiens L-ornithine + urea
-
 ?

Synonyms

Synonyms Comment Organism
arginase II
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information estimated Ki for several inhibitors, overview, inhibition kinetics Homo sapiens
0.0000085
-
 2(S)-amino-6-boronohexanoic acid pH 9.5, 22°C Homo sapiens
0.00003
-
 (S)-(2-boronoethyl)-L-cysteine pH 9.5, 22°C Homo sapiens
0.000051
-
 Nomega-hydroxy-nor-L-arginine pH 7.5, 22°C Homo sapiens
0.00025
-
 2(S)-amino-6-boronohexanoic acid pH 7.5, 22°C Homo sapiens
0.00031
-
 (S)-(2-boronoethyl)-L-cysteine pH 7.5, 22°C Homo sapiens
0.0016
-
 Nomega-hydroxy-L-arginine pH 7.5, 22°C Homo sapiens