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Literature summary for 3.5.3.1 extracted from

  • Di Costanzo, L.; Sabio, G.; Mora, A.; Rodriguez, P.C.; Ochoa, A.C.; Centeno, F.; Christianson, D.W.
    Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response (2005), Proc. Natl. Acad. Sci. USA, 102, 13058-13063.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitors 2(S)-amino-6-boronohexanoic acid or S-(2-boronoethyl)-L-cysteine Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2(S)-amino-6-boronohexanoic acid Kd-value 5 nM, complete inhibition of enzyme in cytoplasmic extracts of myeloid suppressor cells by 0.05 mM Homo sapiens
S-(2-boronoethyl)-L-cysteine Kd-value 270 nM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
L-arginine pH 9.5 Homo sapiens
0.08
-
L-arginine pH 8.5 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ binuclear cluster Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P05089 isoform arginase I
-

Reaction

Reaction Comment Organism Reaction ID
L-arginine + H2O = L-ornithine + urea H141 as general acid to protonate the leaving amino group of L-ornithine during catalysis Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine + H2O
-
Homo sapiens L-ornithine + urea
-
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