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Literature summary for 3.5.3.1 extracted from

  • Maharem, T.M.; Zahran, W.E.; Hassan, R.E.; Abdel Fattah, M.M.
    Unique properties of arginase purified from camel liver cytosol (2018), Int. J. Biol. Macromol., 108, 88-97 .
    View publication on PubMed
Search for more literature for 3.5.3.1

Inhibitors

Inhibitors Comment Organism Structure
DL-isoleucine competitive inhibitor Camelus dromedarius
L-leucine competitive inhibitor Camelus dromedarius
L-lysine competitive inhibitor Camelus dromedarius
L-ornithine competitive inhibitor Camelus dromedarius
L-valine competitive inhibitor Camelus dromedarius
Sr2+ potent inhibitor Camelus dromedarius
Zn2+ potent inhibitor Camelus dromedarius

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.1
-
 L-arginine pH 7.5, 37°C Camelus dromedarius

Localization

Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ the enzyme retains 38.7% of its original activity after dialysis. In the presence of Mn2+ as a cofactor, the enzyme regains 95% of its initial activity Camelus dromedarius
Fe3+ the enzyme retains 38.7% of its original activity after dialysis. In the presence of Mn2+ as a cofactor, the enzyme regains 95% of its initial activity Camelus dromedarius
Mn2+ the enzyme retains 38.7% of its original activity after dialysis. In the presence of Mn2+ as a cofactor, the enzyme regains 96% of its initial activity Camelus dromedarius

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
180000
-
-
 Camelus dromedarius

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine + H2O Camelus dromedarius the enzyme involved in urea cycle L-ornithine + urea
-
 ?

Organism

Organism UniProt Comment Textmining
Camelus dromedarius
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Camelus dromedarius

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Camelus dromedarius
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine + H2O
-
 Camelus dromedarius L-ornithine + urea
-
 ?
L-arginine + H2O the enzyme involved in urea cycle Camelus dromedarius L-ornithine + urea
-
 ?

Subunits

Subunits Comment Organism
? x * 35000, SDS-PAGE Camelus dromedarius

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
70
-
-
 Camelus dromedarius

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
45 80 45°C: about 45% of maximal activity, 80°C: about 75% of maximal activity Camelus dromedarius

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
 activity as a function of pH increases as the pH increases up to pH 9 and pH 10.7 of 50 mM Tris-HCl buffer and 50 mM carbonate bicarbonate buffer Camelus dromedarius
10.7
-
 activity as a function of pH increases as the pH increases up to pH 9 and pH 10.7 of 50 mM Tris-HCl buffer and 50 mM carbonate bicarbonate buffer Camelus dromedarius

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5
-
 L-valine pH 7.5, 37°C Camelus dromedarius
8
-
 L-lysine pH 7.5, 37°C Camelus dromedarius
10
-
 L-leucine pH 7.5, 37°C Camelus dromedarius
17.5
-
 DL-isoleucine pH 7.5, 37°C Camelus dromedarius
30
-
 L-ornithine pH 7.5, 37°C Camelus dromedarius

pI Value

Organism Comment pI Value Maximum pI Value
Camelus dromedarius isoelectric focusing
-
 7.7

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
9
-
 pH 7.5, 37°C Camelus dromedarius L-leucine
9.5
-
 pH 7.5, 37°C Camelus dromedarius DL-isoleucine
13
-
 pH 7.5, 37°C Camelus dromedarius L-valine
22
-
 pH 7.5, 37°C Camelus dromedarius L-lysine
24
-
 pH 7.5, 37°C Camelus dromedarius L-ornithine

General Information

General Information Comment Organism
metabolism the enzyme involved in urea cycle Camelus dromedarius