Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DL-isoleucine | competitive inhibitor | Camelus dromedarius | |
L-leucine | competitive inhibitor | Camelus dromedarius | |
L-lysine | competitive inhibitor | Camelus dromedarius | |
L-ornithine | competitive inhibitor | Camelus dromedarius | |
L-valine | competitive inhibitor | Camelus dromedarius | |
Sr2+ | potent inhibitor | Camelus dromedarius | |
Zn2+ | potent inhibitor | Camelus dromedarius |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
7.1 | - |
L-arginine | pH 7.5, 37°C | Camelus dromedarius |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | the enzyme retains 38.7% of its original activity after dialysis. In the presence of Mn2+ as a cofactor, the enzyme regains 95% of its initial activity | Camelus dromedarius | |
Fe3+ | the enzyme retains 38.7% of its original activity after dialysis. In the presence of Mn2+ as a cofactor, the enzyme regains 95% of its initial activity | Camelus dromedarius | |
Mn2+ | the enzyme retains 38.7% of its original activity after dialysis. In the presence of Mn2+ as a cofactor, the enzyme regains 96% of its initial activity | Camelus dromedarius |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
180000 | - |
- |
Camelus dromedarius |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-arginine + H2O | Camelus dromedarius | the enzyme involved in urea cycle | L-ornithine + urea | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Camelus dromedarius | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Camelus dromedarius |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Camelus dromedarius | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-arginine + H2O | - |
Camelus dromedarius | L-ornithine + urea | - |
? | |
L-arginine + H2O | the enzyme involved in urea cycle | Camelus dromedarius | L-ornithine + urea | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 35000, SDS-PAGE | Camelus dromedarius |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
70 | - |
- |
Camelus dromedarius |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
45 | 80 | 45°C: about 45% of maximal activity, 80°C: about 75% of maximal activity | Camelus dromedarius |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
activity as a function of pH increases as the pH increases up to pH 9 and pH 10.7 of 50 mM Tris-HCl buffer and 50 mM carbonate bicarbonate buffer | Camelus dromedarius |
10.7 | - |
activity as a function of pH increases as the pH increases up to pH 9 and pH 10.7 of 50 mM Tris-HCl buffer and 50 mM carbonate bicarbonate buffer | Camelus dromedarius |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
5 | - |
L-valine | pH 7.5, 37°C | Camelus dromedarius | |
8 | - |
L-lysine | pH 7.5, 37°C | Camelus dromedarius | |
10 | - |
L-leucine | pH 7.5, 37°C | Camelus dromedarius | |
17.5 | - |
DL-isoleucine | pH 7.5, 37°C | Camelus dromedarius | |
30 | - |
L-ornithine | pH 7.5, 37°C | Camelus dromedarius |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Camelus dromedarius | isoelectric focusing | - |
7.7 |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
9 | - |
pH 7.5, 37°C | Camelus dromedarius | L-leucine | |
9.5 | - |
pH 7.5, 37°C | Camelus dromedarius | DL-isoleucine | |
13 | - |
pH 7.5, 37°C | Camelus dromedarius | L-valine | |
22 | - |
pH 7.5, 37°C | Camelus dromedarius | L-lysine | |
24 | - |
pH 7.5, 37°C | Camelus dromedarius | L-ornithine |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme involved in urea cycle | Camelus dromedarius |