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Literature summary for 3.5.3.6 extracted from

  • Izzo, F.; Montella, M.; Orlando, A.P.; Nasti, G.; Beneduce, G.; Castello, G.; Cremona, F.; Ensor, C.M.; Holtzberg, F.W.; Bomalaski, J.S.; Clark, M.A.; Curley, S.A.; Orlando, R.; Scordino, F.; Korba, B.E.
    Pegylated arginine deiminase lowers hepatitis C viral titers and inhibits nitric oxide synthesis (2007), J. Gastroenterol. Hepatol., 22, 86-91.
    View publication on PubMed
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Application

Application Comment Organism
medicine arginine deiminase conjugated to PEG 20 000 reduces extracellular arginine, has minimal toxicity, decreases tumor burden and improves liver function in patients with chronic hepatitis C virus infection and inoperable hepatocellular carcinoma, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine + H2O Homo sapiens the enzyme reduces extracellular arginine, which inhibits viral replication, ADI bound to PEG 20 000 probably reduces hepatitis C virus viral titers through nitric oxide-dependent effects L-citrulline + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine + H2O
-
 Homo sapiens L-citrulline + NH3
-
 ?
L-arginine + H2O the enzyme reduces extracellular arginine, which inhibits viral replication, ADI bound to PEG 20 000 probably reduces hepatitis C virus viral titers through nitric oxide-dependent effects Homo sapiens L-citrulline + NH3
-
 ?

Synonyms

Synonyms Comment Organism
ADI
-
 Homo sapiens
arginine-degrading enzyme
-
 Homo sapiens