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Literature summary for 3.5.4.1 extracted from

  • Kim, T.H.; Yu, T.S.
    Chemical modification of extracellular cytosine deaminase from Chromobacterium violaceum YK 391 (1998), J. Microbiol. Biotechnol., 8, 581-587.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide 1.0 mM + glycine methyl ester, relative activity 102% Chromobacterium violaceum
ethylacetoimidate
-
Aspergillus fumigatus
ethylacetoimidate 1.0 mM, relative activity 102% Chromobacterium violaceum

Application

Application Comment Organism
medicine
-
Escherichia coli
medicine
-
Saccharomyces cerevisiae
medicine treatment of cancer by infecting or implanting cytosine deaminase capsules near the tumor of a cancer patient Chromobacterium violaceum

Inhibitors

Inhibitors Comment Organism Structure
alpha,alpha'-dipyridyl
-
Chromobacterium violaceum
Cd2+
-
Aspergillus fumigatus
Cd2+
-
Chromobacterium violaceum
Cd2+
-
Serratia marcescens
Chloramine T
-
Aspergillus fumigatus
Chloramine T
-
Chromobacterium violaceum
Cu2+
-
Aspergillus fumigatus
Cu2+
-
Chromobacterium violaceum
Cu2+
-
Escherichia coli
Cu2+
-
Salmonella enterica subsp. enterica serovar Typhimurium
Cu2+
-
Serratia marcescens
diethyldicarbonate
-
Chromobacterium violaceum
Fe2+
-
Aspergillus fumigatus
Fe2+
-
Chromobacterium violaceum
Hg2+
-
Aspergillus fumigatus
Hg2+
-
Chromobacterium violaceum
Hg2+
-
Escherichia coli
Hg2+
-
Serratia marcescens
o-phenanthroline
-
Aspergillus fumigatus
o-phenanthroline
-
Chromobacterium violaceum
o-phenanthroline
-
Escherichia coli
o-phenanthroline
-
Saccharomyces cerevisiae
p-chloromercuribenzoic acid
-
Aspergillus fumigatus
p-chloromercuribenzoic acid
-
Chromobacterium violaceum
p-chloromercuribenzoic acid
-
Escherichia coli
p-chloromercuribenzoic acid
-
Paenibacillus polymyxa
p-hydroxymercuribenzoate
-
Chromobacterium violaceum
phenylmethylsulfonyl fluoride
-
Aspergillus fumigatus
phenylmethylsulfonyl fluoride
-
Chromobacterium violaceum
pyridoxal-5'-phosphate
-
Aspergillus fumigatus
pyridoxal-5'-phosphate
-
Chromobacterium violaceum

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Chromobacterium violaceum
-
-
extracellular
-
Arthrobacter sp.
-
-
extracellular
-
Aspergillus fumigatus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
Escherichia coli
Fe2+
-
Chromobacterium violaceum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
78000
-
2 * 78000 Chromobacterium violaceum
156000
-
-
Chromobacterium violaceum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine + H2O Salmonella enterica subsp. enterica serovar Typhimurium
-
uracil + NH3
-
?
cytosine + H2O Escherichia coli
-
uracil + NH3
-
?
cytosine + H2O Saccharomyces cerevisiae
-
uracil + NH3
-
?
cytosine + H2O Chromobacterium violaceum
-
uracil + NH3
-
?
cytosine + H2O Serratia marcescens
-
uracil + NH3
-
?
cytosine + H2O Arthrobacter sp.
-
uracil + NH3
-
?
cytosine + H2O Paenibacillus polymyxa
-
uracil + NH3
-
?
cytosine + H2O Aspergillus fumigatus
-
uracil + NH3
-
?
cytosine + H2O Pseudomonas chlororaphis subsp. aureofaciens
-
uracil + NH3
-
?
cytosine + H2O Chromobacterium violaceum YK 391
-
uracil + NH3
-
?

Organism

Organism UniProt Comment Textmining
Arthrobacter sp.
-
-
-
Aspergillus fumigatus
-
-
-
Chromobacterium violaceum
-
YK 391
-
Chromobacterium violaceum YK 391
-
YK 391
-
Escherichia coli
-
-
-
Paenibacillus polymyxa
-
-
-
Pseudomonas chlororaphis subsp. aureofaciens
-
-
-
Saccharomyces cerevisiae
-
baker's yeast
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
Serratia marcescens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Chromobacterium violaceum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorocytosine + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium 5-fluorouracil + NH3
-
?
5-fluorocytosine + H2O
-
Escherichia coli 5-fluorouracil + NH3
-
?
5-fluorocytosine + H2O
-
Saccharomyces cerevisiae 5-fluorouracil + NH3
-
?
5-fluorocytosine + H2O
-
Chromobacterium violaceum 5-fluorouracil + NH3
-
?
5-fluorocytosine + H2O
-
Aspergillus fumigatus 5-fluorouracil + NH3
-
?
5-fluorocytosine + H2O
-
Chromobacterium violaceum YK 391 5-fluorouracil + NH3
-
?
5-methylcytosine + H2O
-
Saccharomyces cerevisiae thymine + NH3
-
?
5-methylcytosine + H2O
-
Chromobacterium violaceum thymine + NH3
-
?
5-methylcytosine + H2O
-
Aspergillus fumigatus thymine + NH3
-
?
5-methylcytosine + H2O
-
Pseudomonas chlororaphis subsp. aureofaciens thymine + NH3
-
?
5-methylcytosine + H2O
-
Chromobacterium violaceum YK 391 thymine + NH3
-
?
cytosine + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium uracil + NH3
-
?
cytosine + H2O
-
Escherichia coli uracil + NH3
-
?
cytosine + H2O
-
Saccharomyces cerevisiae uracil + NH3
-
?
cytosine + H2O
-
Chromobacterium violaceum uracil + NH3
-
?
cytosine + H2O
-
Serratia marcescens uracil + NH3
-
?
cytosine + H2O
-
Arthrobacter sp. uracil + NH3
-
?
cytosine + H2O
-
Paenibacillus polymyxa uracil + NH3
-
?
cytosine + H2O
-
Aspergillus fumigatus uracil + NH3
-
?
cytosine + H2O
-
Pseudomonas chlororaphis subsp. aureofaciens uracil + NH3
-
?
cytosine + H2O
-
Chromobacterium violaceum YK 391 uracil + NH3
-
?

Subunits

Subunits Comment Organism
dimer 2 * 78000 Chromobacterium violaceum