Application | Comment | Organism |
---|---|---|
medicine | endothelium-specific GTPCH I overexpression retards the progression of hypertension through preservation of the structure and function of resistance mesenteric arteries, endothelium-specific GTPCH I overexpression abrogates superoxide anion production and preserves endothelial nitric oxide synthase phosphorylation, which results in preserved structural and functional integrity of resistance mesenteric arteries and lowered blood pressure in low-renin hypertension | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Mus musculus | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | GTPCH I is the rate-limiting enzyme for de novo tetrahydrobiopterin synthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | GTPCH I is the rate-limiting enzyme for de novo tetrahydrobiopterin synthesis | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GTP cyclohydrolase I | - |
Homo sapiens |
GTPCH I | - |
Homo sapiens |