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Literature summary for 3.5.4.3 extracted from

  • Chakraborty, S.; Shah, N.H.; Fishbein, J.C.; Hosmane, R.S.
    Investigations into specificity of azepinomycin for inhibition of guanase: discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues (2012), Bioorg. Med. Chem. Lett., 22, 7214-7218.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(6R)-6-hydroxy-3-beta-D-ribofuranosyl-3a,4,5,6,7,8a-hexahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one competitive inhibition Oryctolagus cuniculus
(6S)-6-hydroxy-3-beta-D-ribofuranosyl-3a,4,5,6,7,8a-hexahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one competitive inhibition Oryctolagus cuniculus
azepinomycin competitive inhibition Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
guanine + H2O Oryctolagus cuniculus
-
xanthine + NH3
-
?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guanine + H2O
-
Oryctolagus cuniculus xanthine + NH3
-
?

Synonyms

Synonyms Comment Organism
GDA
-
Oryctolagus cuniculus
guanase
-
Oryctolagus cuniculus
Guanine aminohydrolase
-
Oryctolagus cuniculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0025
-
azepinomycin at 25°C and pH 7.4 Oryctolagus cuniculus
0.119
-
(6S)-6-hydroxy-3-beta-D-ribofuranosyl-3a,4,5,6,7,8a-hexahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one at 25°C and pH 7.4 Oryctolagus cuniculus
0.129
-
(6R)-6-hydroxy-3-beta-D-ribofuranosyl-3a,4,5,6,7,8a-hexahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one at 25°C and pH 7.4 Oryctolagus cuniculus