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Literature summary for 3.6.1.1 extracted from

  • Reichert, W.H.; Lauter, C.J.; Trams, E.G.
    Inorganic pyrophosphatase in cultured cells (1974), Biochim. Biophys. Acta, 370, 556-563.
    View publication on PubMed
Search for more literature for 3.6.1.1

Inhibitors

Inhibitors Comment Organism Structure
ADP partially inhibited Homo sapiens
AMP partially inhibited Homo sapiens
ATP partially inhibited Homo sapiens
Ca2+
-
 Mus sp.
Co2+
-
 Homo sapiens
EDTA
-
 Mus sp.
Mn2+
-
 Mus sp.
Zn2+
-
 Mus sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
 diphosphate
-
 Mus sp.
0.25 1.67 diphosphate varying Mg2+ and EDTA concentrations Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens
Mg2+
-
 Mus sp.
additional information no divalent cations required for activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
diphosphate + H2O Homo sapiens
-
 2 phosphate
-
 ?
diphosphate + H2O Mus sp.
-
 2 phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus sp.
-
 mouse
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast cell culture Mus sp.
-
nasopharynx carcinoma cell cell culture Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diphosphate + H2O
-
 Homo sapiens 2 phosphate
-
 ?
diphosphate + H2O
-
 Mus sp. 2 phosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Mus sp.
8
-
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6 9 about 8% and 40% relative activity at pH 6 and 9 respectively, 5 mM diphosphate Homo sapiens
6 9 about 45% and 85% relative activity at pH 6 and 9 respectively, 5 mM diphosphate, 3.2 mM Mg2+ Mus sp.