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Literature summary for 3.6.1.17 extracted from
- Diguanosinetetraphosphatase from rat liver: Activity on diadenosine tetraphosphate and inhibition by adenosine tetraphosphate (1975), Eur. J. Biochem., 50, 495-501.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenosine 5'-tetraphosphate | Ki in nanomolar range | Rattus norvegicus |  |
| guanosine 5'-tetraphosphate | Ki in nanomolar range | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.002 | - |
P1,P4-bis(5'-adenosyl) tetraphosphate | - |
Rattus norvegicus | |
| 0.002 | - |
P1,P4-bis(5'-guanosyl) tetraphosphate | - |
Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required, maximum activity at 5 mM | Rattus norvegicus | |
| Mn2+ | 15% of maximum activity | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 22000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | Rattus norvegicus | - |
ATP + AMP | - |
? | |
| P1,P4-bis(5'-guanosyl)tetraphosphate + H2O | Rattus norvegicus | - |
GTP + GMP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Rattus norvegicus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.002 | - |
crude extract | Rattus norvegicus |
| 0.436 | - |
partially purified enzyme | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | - |
Rattus norvegicus | ATP + AMP | - |
? | |
| P1,P4-bis(5'-guanosyl)tetraphosphate + H2O | - |
Rattus norvegicus | GTP + GMP | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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