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Literature summary for 3.6.1.23 extracted from

  • Moroz, O.V.; Harkiolaki, M.; Galperin, M.Y.; Vagin, A.A.; Gonzalez-Pacanowska, D.; Wilson, K.S.
    The crystal structure of a complex of Campylobacter jejuni dUTPase with substrate analogue sheds light on the mechanism and suggests the "basic module" for dimeric d(C/U)TPases (2004), J. Mol. Biol., 342, 1583-1597.
    View publication on PubMed
Search for more literature for 3.6.1.23

Application

Application Comment Organism
medicine potential drug target Campylobacter jejuni

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) Campylobacter jejuni

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Campylobacter jejuni

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required, three ions per subunit Campylobacter jejuni

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dUTP + H2O Campylobacter jejuni removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA dUMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Campylobacter jejuni
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein Campylobacter jejuni

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dUTP + H2O
-
 Campylobacter jejuni dUMP + diphosphate
-
 ?
dUTP + H2O removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA Campylobacter jejuni dUMP + diphosphate
-
 ?

Subunits

Subunits Comment Organism
dimer crystal structure analysis Campylobacter jejuni