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Literature summary for 3.6.1.23 extracted from

  • Nguyen, C.; Kasinathan, G.; Leal-Cortijo, I.; Musso-Buendia, A.; Kaiser, M.; Brun, R.; Ruiz-Perez, L.M.; Johansson, N.G.; Gonzalez-Pacanowska, D.; Gilbert, I.H.
    Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target (2005), J. Med. Chem., 48, 5942-5954.
    View publication on PubMed
Search for more literature for 3.6.1.23

Application

Application Comment Organism
drug development the enzyme is a potential antiparasitic drug target Homo sapiens
drug development the enzyme is a potential antiparasitic drug target Leishmania donovani
drug development the enzyme is a potential antiparasitic drug target Plasmodium falciparum
drug development the enzyme is a potential antiparasitic drug target Leishmania major

Inhibitors

Inhibitors Comment Organism Structure
2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate
-
 Homo sapiens
2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate
-
 Leishmania donovani
2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate
-
 Leishmania major
2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate
-
 Plasmodium falciparum
2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Homo sapiens
2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Leishmania donovani
2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Leishmania major
2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Plasmodium falciparum
3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Homo sapiens
3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Leishmania donovani
3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Leishmania major
3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Plasmodium falciparum
3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine
-
 Homo sapiens
3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine
-
 Leishmania donovani
3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine
-
 Leishmania major
3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine
-
 Plasmodium falciparum
5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine
-
 Homo sapiens
5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine
-
 Leishmania donovani
5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine
-
 Leishmania major
5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine
-
 Plasmodium falciparum
5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Homo sapiens
5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Leishmania donovani
5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Leishmania major
5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Plasmodium falciparum
5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Homo sapiens
5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Leishmania donovani
5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Leishmania major
5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Plasmodium falciparum
5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine
-
 Homo sapiens
5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine
-
 Leishmania donovani
5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine
-
 Leishmania major
5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine
-
 Plasmodium falciparum
5'-O-triphenylsilyl-2'-deoxyuridine
-
 Homo sapiens
5'-O-triphenylsilyl-2'-deoxyuridine
-
 Leishmania donovani
5'-O-triphenylsilyl-2'-deoxyuridine
-
 Leishmania major
5'-O-triphenylsilyl-2'-deoxyuridine
-
 Plasmodium falciparum
5'-pentanoylamino-2',5'-dideoxyuridine
-
 Homo sapiens
5'-pentanoylamino-2',5'-dideoxyuridine
-
 Leishmania donovani
5'-pentanoylamino-2',5'-dideoxyuridine
-
 Leishmania major
5'-pentanoylamino-2',5'-dideoxyuridine
-
 Plasmodium falciparum
5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine
-
 Homo sapiens
5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine
-
 Leishmania donovani
5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine
-
 Leishmania major
5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine
-
 Plasmodium falciparum
5'-tritylamino-2',5'-dideoxyuridine
-
 Homo sapiens
5'-tritylamino-2',5'-dideoxyuridine
-
 Leishmania donovani
5'-tritylamino-2',5'-dideoxyuridine
-
 Leishmania major
5'-tritylamino-2',5'-dideoxyuridine
-
 Plasmodium falciparum
5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine
-
 Homo sapiens
5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine
-
 Leishmania donovani
5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine
-
 Leishmania major
5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine
-
 Plasmodium falciparum
additional information inhibitor in vivo activity against the parasite, overview Homo sapiens
additional information inhibitor in vivo activity against the parasite, overview Leishmania donovani
additional information inhibitor in vivo activity against the parasite, overview Leishmania major
additional information inhibitor in vivo activity against the parasite, overview Plasmodium falciparum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens
Mg2+
-
 Leishmania donovani
Mg2+
-
 Plasmodium falciparum
Mg2+
-
 Leishmania major

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dUTP + H2O Homo sapiens
-
 dUMP + diphosphate
-
 ?
dUTP + H2O Leishmania donovani
-
 dUMP + diphosphate
-
 ?
dUTP + H2O Plasmodium falciparum
-
 dUMP + diphosphate
-
 ?
dUTP + H2O Leishmania major
-
 dUMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Leishmania donovani
-
-
-
Leishmania major
-
-
-
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dUTP + H2O
-
 Homo sapiens dUMP + diphosphate
-
 ?
dUTP + H2O
-
 Leishmania donovani dUMP + diphosphate
-
 ?
dUTP + H2O
-
 Plasmodium falciparum dUMP + diphosphate
-
 ?
dUTP + H2O
-
 Leishmania major dUMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
deoxyuridine triphosphate nucleotidohydrolase
-
 Homo sapiens
deoxyuridine triphosphate nucleotidohydrolase
-
 Leishmania donovani
deoxyuridine triphosphate nucleotidohydrolase
-
 Plasmodium falciparum
deoxyuridine triphosphate nucleotidohydrolase
-
 Leishmania major
dUTPase
-
 Homo sapiens
dUTPase
-
 Leishmania donovani
dUTPase
-
 Plasmodium falciparum
dUTPase
-
 Leishmania major

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0002
-
 5'-tritylamino-2',5'-dideoxyuridine
-
 Plasmodium falciparum
0.0013
-
 5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Plasmodium falciparum
0.0028
-
 5'-O-triphenylsilyl-2'-deoxyuridine
-
 Plasmodium falciparum
0.012
-
 5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine
-
 Plasmodium falciparum
0.026
-
 2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Plasmodium falciparum
0.046
-
 5'-tritylamino-2',5'-dideoxyuridine
-
 Homo sapiens
0.058
-
 5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine
-
 Plasmodium falciparum
0.067
-
 3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Plasmodium falciparum
0.082
-
 5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Plasmodium falciparum
0.088
-
 3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine
-
 Plasmodium falciparum
0.089
-
 5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine
-
 Plasmodium falciparum
0.099
-
 2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate
-
 Plasmodium falciparum
0.189
-
 5'-pentanoylamino-2',5'-dideoxyuridine
-
 Plasmodium falciparum
0.232
-
 3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Homo sapiens
0.298
-
 5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine
-
 Homo sapiens
0.304
-
 5'-tritylamino-2',5'-dideoxyuridine
-
 Leishmania major
0.324
-
 3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine
-
 Homo sapiens
0.35
-
 5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Leishmania major
0.433
-
 5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine
-
 Leishmania major
0.799
-
 5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Homo sapiens
0.808
-
 5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine
-
 Homo sapiens
0.909
-
 5'-O-triphenylsilyl-2'-deoxyuridine
-
 Homo sapiens
0.975
-
 5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine
-
 Plasmodium falciparum
1
-
 5'-O-triphenylsilyl-2'-deoxyuridine above Leishmania major
1
-
 2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate above Homo sapiens
1
-
 2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate above Leishmania major
1
-
 5'-pentanoylamino-2',5'-dideoxyuridine above Homo sapiens
1
-
 5'-pentanoylamino-2',5'-dideoxyuridine above Leishmania major
1
-
 3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine above Leishmania major
1
-
 3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate above Leishmania major
1
-
 5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine above Leishmania major
1
-
 5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine above Homo sapiens
1
-
 5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine above Leishmania major
1
-
 5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine above Homo sapiens
1
-
 5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine above Leishmania major
1
-
 2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate above Homo sapiens
1
-
 2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate above Leishmania major
1
-
 5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine above Leishmania major
1
-
 5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine above Homo sapiens