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Literature summary for 3.6.1.23 extracted from

  • Stout, C.D.
    Induced fit, drug design, and dUTPase (2004), Structure, 12, 2-3.
    View publication on PubMed
Search for more literature for 3.6.1.23

Application

Application Comment Organism
drug development induced fit drug design Trypanosoma cruzi

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme in complex with inhibitor dUDP, crystal structure determination and analysis Trypanosoma cruzi

Inhibitors

Inhibitors Comment Organism Structure
dUDP binding structure Trypanosoma cruzi

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dUTP + H2O Trypanosoma cruzi the reaction produces the primary source of substrate for synthesis of dTTP and reduces the intracellular dUTP concentration, thus limiting the misincorporation of uracil into DNA dUMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Reaction

Reaction Comment Organism Reaction ID
dUTP + H2O = dUMP + diphosphate structural and catalytic mechanism Trypanosoma cruzi
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dUTP + H2O the reaction produces the primary source of substrate for synthesis of dTTP and reduces the intracellular dUTP concentration, thus limiting the misincorporation of uracil into DNA Trypanosoma cruzi dUMP + diphosphate
-
 ?
dUTP + H2O substrate binding structure analysis, overview Trypanosoma cruzi dUMP + diphosphate
-
 ?

Subunits

Subunits Comment Organism
dimer cyrstal structure analysis, overview Trypanosoma cruzi

Synonyms

Synonyms Comment Organism
dUTPase
-
 Trypanosoma cruzi