Cloned (Comment) | Organism |
---|---|
expression in Schneider 2 cells | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | 21 kDa isozyme, the 21 kDa isozyme is excluded from the nuclei during interphase, it is shifted to the nucleus during prophase and forthcoming mitotic steps | Drosophila melanogaster | 5737 | - |
additional information | both isoforms can be present within the nuclear microenvironment, although at different stages of cell cycle by strict timing to the nuclear cleavage phases | Drosophila melanogaster | - |
- |
nucleus | 23 kDa isozyme, the 21 kDa isozyme is excluded from the nuclei during interphase, it is shifted to the nucleus during prophase and forthcoming mitotic steps | Drosophila melanogaster | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
21000 | - |
x * 21000, isozyme 1, SDS-PAGE, x * 23000, isozyme 2, SDS-PAGE | Drosophila melanogaster |
23000 | - |
x * 21000, isozyme 1, SDS-PAGE, x * 23000, isozyme 2, SDS-PAGE | Drosophila melanogaster |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dUTP + H2O | Drosophila melanogaster | an efficient preventive repair pathway, avoiding uracil in DNA, is generally present that keeps cellular dUTP/dTTP levels at a much decreased value to prevent use of dUTP as a building block by DNA polymerases. The enzyme responsible for this sanitizing role is dUTPase, a ubiquitous protein | dUMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
two dUTPase isozymes | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | at the syncytial blastoderm stage, localization shifts of dUTPase isozymes within embryos, overview | Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dUTP + H2O | - |
Drosophila melanogaster | dUMP + diphosphate | - |
? | |
dUTP + H2O | an efficient preventive repair pathway, avoiding uracil in DNA, is generally present that keeps cellular dUTP/dTTP levels at a much decreased value to prevent use of dUTP as a building block by DNA polymerases. The enzyme responsible for this sanitizing role is dUTPase, a ubiquitous protein | Drosophila melanogaster | dUMP + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 21000, isozyme 1, SDS-PAGE, x * 23000, isozyme 2, SDS-PAGE | Drosophila melanogaster |
Synonyms | Comment | Organism |
---|---|---|
dUTPase | - |
Drosophila melanogaster |