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Literature summary for 3.6.1.23 extracted from
- The nucleotidohydrolases DCTPP1 and dUTPase are involved in the cellular response to decitabine (2016), Biochem. J., 473, 2635-2643 .
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | the enzyme is a factors involved in the mode of action of decitabine with potential value as enzymatic targets to improve decitabine-based chemotherapy | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dUTP + H2O | Homo sapiens | - |
dUMP + diphosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | P33316 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dUTP + H2O | - |
Homo sapiens | dUMP + diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| deoxyuridine triphosphate nucleotidohydrolase | - |
Homo sapiens |
| dUTPase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | exposure of HeLa cells to decitabine upregulates the expression of several pyrimidine metabolic enzymes including DCTPP1, dUTPase, dCMP deaminase and thymidylate synthase | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | dUTPase down-regulation increases decitabine-induced toxicity in HeLa and MRC-5 cells at a wide range of doses | Homo sapiens |
| metabolism | the enzyme contributes to the cellular response to the anti-cancer nucleoside decitabine. Exposure of HeLa cells to decitabine upregulates the expression of several pyrimidine metabolic enzymes including DCTPP1, dUTPase, dCMP deaminase and thymidylate synthase. dUTPase down-regulation enhances the cytotoxic effect of decitabine producing an accumulation of nucleoside triphosphates containing uracil as well as uracil misincorporation and double-strand breaks in genomic DNA | Homo sapiens |
| metabolism | the enzyme is involved de novo biosynthesis of dTTP and sanitizing the deoxynucleotide pool by the specific removal of dUTP | Homo sapiens |
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