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Literature summary for 3.6.1.23 extracted from

  • Benedek, A.; Poeloeskei, I.; Ozohanics, O.; Vekey, K.; Vertessy, B.G.
    The Stl repressor from Staphylococcus aureus is an efficient inhibitor of the eukaryotic fruitfly dUTPase (2018), FEBS Open Bio, 8, 158-167 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.23

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 (DE3) Rosetta cells Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
Stl repressor protein from Staphylococcus aureus
-
 Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dUTP + H2O Drosophila melanogaster
-
 dUMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography and Superose 12 gel filtration Drosophila melanogaster

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dUTP + H2O
-
 Drosophila melanogaster dUMP + diphosphate
-
 ?

Subunits

Subunits Comment Organism
trimer
-
 Drosophila melanogaster

Synonyms

Synonyms Comment Organism
dUTPase
-
 Drosophila melanogaster

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
53.3
-
 melting temperature Drosophila melanogaster

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00003
-
 at pH 7.5 and 20°C Drosophila melanogaster Stl repressor protein from Staphylococcus aureus