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Literature summary for 3.6.1.23 extracted from
- dUTPase the frequently overlooked enzyme encoded by many retroviruses (2015), Retrovirology, 12, 70 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D48E/N57S | active site mutant | bovine immunodeficiency virus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dUTP + H2O | Saccharomyces cerevisiae | - |
dUMP + diphosphate | - |
? |  |
| dUTP + H2O | Caenorhabditis elegans | - |
dUMP + diphosphate | - |
? | |
| dUTP + H2O | Mycobacterium tuberculosis | - |
dUMP + diphosphate | - |
? | |
| dUTP + H2O | Plasmodium falciparum | - |
dUMP + diphosphate | - |
? | |
| dUTP + H2O | Human gammaherpesvirus 4 | - |
dUMP + diphosphate | - |
? | |
| dUTP + H2O | Mason-Pfizer monkey virus | - |
dUMP + diphosphate | - |
? | |
| dUTP + H2O | mouse mammary tumor virus | - |
dUMP + diphosphate | - |
? | |
| dUTP + H2O | equine infectious anemia virus | - |
dUMP + diphosphate | - |
? | |
| dUTP + H2O | feline immunodeficiency virus | - |
dUMP + diphosphate | - |
? | |
| dUTP + H2O | Human gammaherpesvirus 8 | - |
dUMP + diphosphate | - |
? | |
| dUTP + H2O | Human endogenous retrovirus K | - |
dUMP + diphosphate | - |
? | |
| dUTP + H2O | Homo sapiens | - |
dUMP + diphosphate | - |
? | |
| dUTP + H2O | bovine immunodeficiency virus | - |
dUMP + diphosphate | - |
? | |
| dUTP + H2O | Escherichia coli | - |
dUMP + diphosphate | - |
? | |
| dUTP + H2O | Murid gammaherpesvirus 4 | - |
dUMP + diphosphate | - |
? | |
| dUTP + H2O | Jembrana disease virus | - |
dUMP + diphosphate | - |
? | |
| dUTP + H2O | Caprine arthritis encephalitis virus | - |
dUMP + diphosphate | - |
? | |
| dUTP + H2O | Visna-maedi virus | - |
dUMP + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| bovine immunodeficiency virus | - |
- |
- |
| Caenorhabditis elegans | - |
- |
- |
| Caprine arthritis encephalitis virus | - |
- |
- |
| equine infectious anemia virus | - |
- |
- |
| Escherichia coli | P06968 | - |
- |
| feline immunodeficiency virus | - |
- |
- |
| Homo sapiens | P33316 | - |
- |
| Human endogenous retrovirus K | - |
- |
- |
| Human gammaherpesvirus 4 | - |
- |
- |
| Human gammaherpesvirus 8 | - |
- |
- |
| Jembrana disease virus | - |
- |
- |
| Mason-Pfizer monkey virus | - |
- |
- |
| mouse mammary tumor virus | - |
- |
- |
| Murid gammaherpesvirus 4 | - |
- |
- |
| Mycobacterium tuberculosis | - |
- |
- |
| Plasmodium falciparum | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Visna-maedi virus | - |
of sheep | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dUTP + H2O | - |
Saccharomyces cerevisiae | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
Caenorhabditis elegans | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
Mycobacterium tuberculosis | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
Plasmodium falciparum | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
Human gammaherpesvirus 4 | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
Mason-Pfizer monkey virus | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
mouse mammary tumor virus | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
equine infectious anemia virus | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
feline immunodeficiency virus | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
Human gammaherpesvirus 8 | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
Human endogenous retrovirus K | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
Homo sapiens | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
bovine immunodeficiency virus | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
Escherichia coli | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
Murid gammaherpesvirus 4 | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
Jembrana disease virus | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
Caprine arthritis encephalitis virus | dUMP + diphosphate | - |
? | |
| dUTP + H2O | - |
Visna-maedi virus | dUMP + diphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homotrimer | - |
Homo sapiens |
| homotrimer | - |
Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Saccharomyces cerevisiae |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Caenorhabditis elegans |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Mycobacterium tuberculosis |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Plasmodium falciparum |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Human gammaherpesvirus 4 |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Mason-Pfizer monkey virus |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
mouse mammary tumor virus |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
equine infectious anemia virus |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
feline immunodeficiency virus |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Human gammaherpesvirus 8 |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Human endogenous retrovirus K |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Homo sapiens |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
bovine immunodeficiency virus |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Escherichia coli |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Murid gammaherpesvirus 4 |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Jembrana disease virus |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Caprine arthritis encephalitis virus |
| deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Visna-maedi virus |
| dUTPase | - |
Saccharomyces cerevisiae |
| dUTPase | - |
Caenorhabditis elegans |
| dUTPase | - |
Mycobacterium tuberculosis |
| dUTPase | - |
Plasmodium falciparum |
| dUTPase | - |
Human gammaherpesvirus 4 |
| dUTPase | - |
Mason-Pfizer monkey virus |
| dUTPase | - |
mouse mammary tumor virus |
| dUTPase | - |
equine infectious anemia virus |
| dUTPase | - |
feline immunodeficiency virus |
| dUTPase | - |
Human gammaherpesvirus 8 |
| dUTPase | - |
Human endogenous retrovirus K |
| dUTPase | - |
Homo sapiens |
| dUTPase | - |
bovine immunodeficiency virus |
| dUTPase | - |
Escherichia coli |
| dUTPase | - |
Murid gammaherpesvirus 4 |
| dUTPase | - |
Jembrana disease virus |
| dUTPase | - |
Caprine arthritis encephalitis virus |
| dUTPase | - |
Visna-maedi virus |
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Release 2023.1 (January 2023)
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