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Literature summary for 3.6.1.9 extracted from
- Biochemical characterization of human PC-1, an enzyme possessing alkaline phosphodiesterase I and nucleotide pyrophosphatase activities (1994), Eur. J. Biochem., 226, 433-443.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Cos-7 and mouse Ltk- cells | Mus musculus |
| expression in Cos-7 and mouse Ltk- cells | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 120000 | - |
2 * 120000, reducing SDS-PAGE | Mus musculus |
| 130000 | - |
2 * 130000, reducing SDS-PAGE, disulfide-bound | Homo sapiens |
| 240000 | - |
non-reducing SDS-PAGE | Mus musculus |
| 260000 | - |
non-reducing SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + H2O | Homo sapiens | - |
AMP + phosphate | - |
? |  |
| ATP + H2O | Mus musculus | - |
AMP + diphosphate | - |
? | |
| ATP + H2O | Homo sapiens | - |
AMP + diphosphate | - |
? | |
| UDP-glucose + H2O | Homo sapiens | - |
UMP + D-glucose-1-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | N-linked oligosaccharides, human 120 kDa-precursor form possesses high-mannose oligosaccharides, which disappear in the mature 130 kDa form | Mus musculus |
| glycoprotein | N-linked oligosaccharides, human 120 kDa-precursor form possesses high-mannose oligosaccharides, which disappear in the mature 130 kDa form | Homo sapiens |
| phosphoprotein | autophosphorylation | Mus musculus |
| phosphoprotein | autophosphorylation | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + H2O | - |
Homo sapiens | AMP + phosphate | - |
? | |
| ATP + H2O | - |
Mus musculus | AMP + diphosphate | - |
? | |
| ATP + H2O | - |
Homo sapiens | AMP + diphosphate | - |
? | |
| p-nitrophenyl phenylphosphonate + H2O | phosphodiesterase-1 activity | Mus musculus | p-nitrophenol + phenylphosphonate | - |
? | |
| p-nitrophenyl phenylphosphonate + H2O | phosphodiesterase-1 activity | Homo sapiens | p-nitrophenol + phenylphosphonate | - |
? | |
| UDP-glucose + H2O | - |
Homo sapiens | UMP + D-glucose-1-phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 130000, reducing SDS-PAGE, disulfide-bound | Homo sapiens |
| dimer | 2 * 120000, reducing SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| nucleotide pyrophosphatase/phosphodiesterase-I | - |
Mus musculus |
| nucleotide pyrophosphatase/phosphodiesterase-I | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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