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Literature summary for 3.6.5.3 extracted from
- Effects of antibiotics, N-acetylaminoacyl-tRNA and other agents on the elongation-factor Tu dependent and ribosome-dependent GTP hydrolysis promoted by 2'(3')-O-L-phenylalanyladenosine (1981), Eur. J. Biochem., 117, 27-31.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| bluensomycin | - |
Escherichia coli |  |
| gentamicin C1 | - |
Escherichia coli | |
| gentamicin C1a | - |
Escherichia coli | |
| hygromycin | - |
Escherichia coli | |
| kanamycin A | - |
Escherichia coli | |
| kanamycin B | - |
Escherichia coli | |
| neomycin C | - |
Escherichia coli | |
| paromycin | - |
Escherichia coli | |
| sisomicin | - |
Escherichia coli | |
| streptomycin | - |
Escherichia coli | |
| tobramycin | - |
Escherichia coli | |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | protein biosynthesis | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chloramphenicol | - |
Escherichia coli | |
| dihydrostreptomycin | - |
Escherichia coli | |
| hygromycin A | - |
Escherichia coli | |
| N-ethylmaleimide | - |
Escherichia coli | |
| neamine | - |
Escherichia coli | |
| neomycin B | - |
Escherichia coli | |
| NH4Cl | at higher concentration | Escherichia coli | |
| ribostamycin | - |
Escherichia coli | |
| sparsomycin | - |
Escherichia coli | |
| streptogramin A | - |
Escherichia coli | |
| viomycin | - |
Escherichia coli | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | Escherichia coli | - |
GDP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
elongations factor (EF)Tu | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Escherichia coli | GDP + phosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
- |
Escherichia coli |
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Release 2023.1 (January 2023)
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