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Literature summary for 3.8.1.7 extracted from

  • Xu, D.; Guo, H.
    Electrostatic influence of active-site waters on the nucleophilic aromatic substitution catalyzed by 4-chlorobenzoyl-CoA dehalogenase (2005), FEBS Lett., 579, 4249-4253.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Pseudomonas sp. A5JTM5
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-chlorobenzoyl-CoA + H2O electrostatic influence of active-site waters on the nucleophilic aromatic substitution catalyzed by 4-chlorobenzoyl-CoA dehalogenase. A quantum mechanical/molecular mechanical simulation of the potential of mean force for the substitution step conforms the increased barrier height in the H90Q mutant and provides the increased barrier height in the H90Q mutant and provides evidence on the electrostatic influence of two-site waters on the rate-limiting barrier Pseudomonas sp. 4-hydroxybenzoyl-CoA + chloride
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