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Literature summary for 4.1.1.1 extracted from
- Pyruvate decarboxylase: a key enzyme for the oxidative metabolism of lactic acid by Acetobacter pasteurianus (2001), Arch. Microbiol., 176, 443-451.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no substrate activation, PDC activity is regulated in response to growth substrate, highest with lactic acid, lower with ethanol or glycerol, and absent with mannitol | Acetobacter pasteurianus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of pdc gene in recombinant Escherichia coli, sequencing, pdc operon | Acetobacter pasteurianus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | cofactor | Acetobacter pasteurianus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 58873 | - |
x * 58873, anhydrous molecular mass, calculated from the amino acid sequence | Acetobacter pasteurianus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate | Acetobacter pasteurianus | key enzyme for the oxidative metabolism of lactic acid | acetaldehyde + CO2 | - |
? | |
| pyruvate | Acetobacter pasteurianus NCIB 8618 / ATCC 12874 | key enzyme for the oxidative metabolism of lactic acid | acetaldehyde + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acetobacter pasteurianus | Q8L388 | - |
- |
| Acetobacter pasteurianus NCIB 8618 / ATCC 12874 | Q8L388 | - |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Acetobacter pasteurianus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate | - |
Acetobacter pasteurianus | acetaldehyde + CO2 | - |
? | |
| pyruvate | key enzyme for the oxidative metabolism of lactic acid | Acetobacter pasteurianus | acetaldehyde + CO2 | - |
? | |
| pyruvate | - |
Acetobacter pasteurianus NCIB 8618 / ATCC 12874 | acetaldehyde + CO2 | - |
? | |
| pyruvate | key enzyme for the oxidative metabolism of lactic acid | Acetobacter pasteurianus NCIB 8618 / ATCC 12874 | acetaldehyde + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 58873, anhydrous molecular mass, calculated from the amino acid sequence | Acetobacter pasteurianus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDC | - |
Acetobacter pasteurianus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| thiamine diphosphate | - |
Acetobacter pasteurianus | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Acetobacter pasteurianus | calculated from the amino acid sequence | - |
5.49 |
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Release 2023.1 (January 2023)
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