Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a good drug target | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S,3R,4S,5S)-2,3,4,6-tetrahydroxy-5-mercaptohexanal | ZINC03871163 | Mycobacterium tuberculosis | |
(2S,3S,4R,5R)tetrahydro-2H-pyran2,3,4,5-tetraol | ZINC03606295 | Mycobacterium tuberculosis | |
(2S,3S,4R,5S)2,5bis(hydroxymethyl)tetrahydrofuran-2,3,4-triol | ZINC03830875 | Mycobacterium tuberculosis | |
(2S,3S,4S,5R)-2(hydroxymethyl) tetrahydro-2H-pyran-2,3,4,5-tetraol | ZINC03830878 | Mycobacterium tuberculosis | |
(S)-5-acetoxy-4-methylpentanoate | ZINC02036492 | Mycobacterium tuberculosis | |
(S)-thiazolidin-3-ium-4-carboxylate | ZINC00967474 | Mycobacterium tuberculosis | |
1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one | ZINC05177572 | Mycobacterium tuberculosis | |
3-amino-4-(propylamino)cyclobutane-1 2-dione | LIGAND10436 | Mycobacterium tuberculosis | |
additional information | potential inhibitor molecule docking using the enzyme's crystal structure, overview | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate | Mycobacterium tuberculosis | - |
beta-alanine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
gene panD | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate | - |
Mycobacterium tuberculosis | beta-alanine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
L-Aspartate alpha-decarboxylase | - |
Mycobacterium tuberculosis |
MtbADC | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyruvoyl cofactor | dependent on | Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
evolution | L-aspartate alpha-decarboxylase belongs to a class of pyruvoyl dependent enzymes | Mycobacterium tuberculosis |
metabolism | L-aspartate alpha-decarboxylase catalyzes the conversion of aspartate to beta-alanine in the pantothenate pathway, which is critical for the growth of Mycobacterium tuberculosis | Mycobacterium tuberculosis |
additional information | the enzyme active site is formed by the interface of a dimer, with relatively small volume. This cleft can support only molecules of relatively small size | Mycobacterium tuberculosis |