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Literature summary for 4.1.1.112 extracted from
- Oxaloacetate decarboxylases of rat liver (1973), Biochem. J., 135, 667-672.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| citrate | 50% inhibition of mitochondrial enzyme at 4.5 mM | Rattus norvegicus |  |
| coenzyme A | 50% inhibition of mitochondrial enzyme at 0.05 mM | Rattus norvegicus | |
| phosphoenolpyruvate | 50% inhibition of mitochondrial enzyme at 28 mM | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.15 | - |
oxaloacetate | - |
Rattus norvegicus | |
| 0.23 | - |
oxaloacetate | mitochondrial enzyme | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | differs from mitochondrial enzyme | Rattus norvegicus | 5737 | - |
| microsome | - |
Rattus norvegicus | - |
- |
| mitochondrion | differs from cytoplasmic enzyme | Rattus norvegicus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | only cytoplasmic enzyme | Rattus norvegicus | |
| Mn2+ | only cytoplasmic enzyme | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| oxaloacetate | Rattus norvegicus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Oxaloacetate | - |
Rattus norvegicus | Pyruvate + CO2 | - |
? | |
| oxaloacetate | - |
Rattus norvegicus | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
enzyme assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
cytoplasmic enzyme | Rattus norvegicus |
| 9.5 | - |
mitochondrial enzyme | Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 10 | - |
Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 28 | - |
phosphoenolpyruvate | mitochondrial enzyme | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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