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Literature summary for 4.1.1.15 extracted from

  • Monnerie, H.; Le Roux, P.D.
    Glutamate alteration of glutamic acid decarboxylase (GAD) in GABAergic neurons: the role of cysteine proteases (2008), Exp. Neurol., 213, 145-153.
    View publication on PubMed
Search for more literature for 4.1.1.15

Inhibitors

Inhibitors Comment Organism Structure
additional information glutamate reduces the expression of isozymes GAD65 and GAD67, glutamate's suppressing effect on GAD protein isoforms is significantly attenuated by preincubation with the cysteine protease inhibitor N-acetyl-L-leucyl-L-leucyl-L-norleucinal via blockade of calpain and cathepsin protease activities, overview Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information removing extracellular calcium prevents the NMDAR-mediated decrease in GAD protein levels, whereas inhibiting calcium entry through voltage-gated calcium channels has no effect Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate Mus musculus
-
 4-aminobutanoate + CO2
-
 ?
L-glutamate Mus musculus BALB/c
-
 4-aminobutanoate + CO2
-
 ?
additional information Mus musculus cortical GABAergic neurons, surviving pathological insult such as ischemia or brain trauma, exposed to glutamate in vitro, display an NMDA receptor-mediated alteration in the levels of the GABA synthesizing enzyme glutamic acid decarboxylase, isozymes GAD65 and 67, mechanism of glutamate excitotoxicity, overview ?
-
 ?
additional information Mus musculus BALB/c cortical GABAergic neurons, surviving pathological insult such as ischemia or brain trauma, exposed to glutamate in vitro, display an NMDA receptor-mediated alteration in the levels of the GABA synthesizing enzyme glutamic acid decarboxylase, isozymes GAD65 and 67, mechanism of glutamate excitotoxicity, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 Balb/c mice
-
Mus musculus BALB/c
-
 Balb/c mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
cerebral cortex
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate
-
 Mus musculus 4-aminobutanoate + CO2
-
 ?
L-glutamate
-
 Mus musculus BALB/c 4-aminobutanoate + CO2
-
 ?
additional information cortical GABAergic neurons, surviving pathological insult such as ischemia or brain trauma, exposed to glutamate in vitro, display an NMDA receptor-mediated alteration in the levels of the GABA synthesizing enzyme glutamic acid decarboxylase, isozymes GAD65 and 67, mechanism of glutamate excitotoxicity, overview Mus musculus ?
-
 ?
additional information cortical GABAergic neurons, surviving pathological insult such as ischemia or brain trauma, exposed to glutamate in vitro, display an NMDA receptor-mediated alteration in the levels of the GABA synthesizing enzyme glutamic acid decarboxylase, isozymes GAD65 and 67, mechanism of glutamate excitotoxicity, overview Mus musculus BALB/c ?
-
 ?

Synonyms

Synonyms Comment Organism
GAD
-
 Mus musculus
Glutamic acid decarboxylase
-
 Mus musculus