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Literature summary for 4.1.1.15 extracted from

  • Hwang, I.K.; Li, H.; Yoo, K.; Choi, J.H.; Lee, C.H.; Chung, D.W.; Kim, D.W.; Seong, J.K.; Yoon, Y.S.; Lee, I.S.; Won, M.
    Comparison of glutamic acid decarboxylase 67 immunoreactive neurons in the hippocampal CA1 region at various age stages in dogs (2008), Neurosci. Lett., 431, 251-255.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate Canis lupus familiaris GAD67 is a rate-limiting enzyme for GABA synthesis, GAD65 is important for the local control of GABA synthesis at the synaptic sites, whereas GAD67 is responsible for maintaining GABA baseline levels for both neurotransmitter and metabolite 4-aminobutanoate + CO2
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additional information Canis lupus familiaris the reduction of GAD67 immunoreactive neurons in the hippocampal CA1 region may be closely related to highly susceptibility to memory loss in old aged dogs ?
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Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
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Source Tissue

Source Tissue Comment Organism Textmining
brain immunoreactive neurons in the hippocampal CA1 region at various age stages, in 1-year-old dogs in the stratum oriens, in 6-year-old dogs in the CA1 region, but scarcely found in the CA1 region in 10-year-old dogs Canis lupus familiaris
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hippocampus
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Canis lupus familiaris
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additional information immunohistochemic analysis of isozyme distributions, overview Canis lupus familiaris
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neuron GABAergic neurons Canis lupus familiaris
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate
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Canis lupus familiaris 4-aminobutanoate + CO2
-
?
L-glutamate GAD67 is a rate-limiting enzyme for GABA synthesis, GAD65 is important for the local control of GABA synthesis at the synaptic sites, whereas GAD67 is responsible for maintaining GABA baseline levels for both neurotransmitter and metabolite Canis lupus familiaris 4-aminobutanoate + CO2
-
?
additional information the reduction of GAD67 immunoreactive neurons in the hippocampal CA1 region may be closely related to highly susceptibility to memory loss in old aged dogs Canis lupus familiaris ?
-
?

Synonyms

Synonyms Comment Organism
GAD67
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Canis lupus familiaris
glutamic acid decarboxylase 67
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Canis lupus familiaris