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Literature summary for 4.1.1.17 extracted from

  • Wrenger, C.; Luersen, K.; Krause, T.; Muller, S.; Walter, R.D.
    The Plasmodium falciparum bifunctional ornithine decarboxylase, S-adenosyl-L-methionine decarboxylase, enables a well balanced polyamine synthesis without domain-domain interaction (2001), J. Biol. Chem., 276, 29651-29656.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of Strep-tactin-PfODC/AdoMetDC fusion in Escherichia coli Plasmodium falciparum

Protein Variants

Protein Variants Comment Organism
C1355A 8.7% of wild-type activity Plasmodium falciparum
D1356A 8% of wild-type activity Plasmodium falciparum
D1359A 3% of wild-type activity Plasmodium falciparum
G1382Y no ODC activity Plasmodium falciparum
K868A no ODC activity Plasmodium falciparum
K970A no ODC activity Plasmodium falciparum
S73A no AdometDC, i.e. ec4.1.1.50, activity, 90% of wild-type ODC activity Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
putrescine
-
Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.041
-
L-ornithine recombinant PfODC Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Plasmodium falciparum first step in polyamine biosynthesis putrescine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant PfODC Plasmodium falciparum

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0388
-
recombinant PfODC Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
Plasmodium falciparum putrescine + CO2
-
?
L-ornithine first step in polyamine biosynthesis Plasmodium falciparum putrescine + CO2
-
?
additional information bifunctional enzyme having both ODC and AdoMetDC, i.e. EC4.1.1.50, activity Plasmodium falciparum ?
-
?

Synonyms

Synonyms Comment Organism
PfODC/AdoMetDC
-
Plasmodium falciparum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Plasmodium falciparum

pH Range

pH Minimum pH Maximum Comment Organism
7 8.5
-
Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.068
-
putrescine
-
Plasmodium falciparum