Cloned (Comment) | Organism |
---|---|
expression of Strep-tactin-PfODC/AdoMetDC fusion in Escherichia coli | Plasmodium falciparum |
Protein Variants | Comment | Organism |
---|---|---|
C1355A | 8.7% of wild-type activity | Plasmodium falciparum |
D1356A | 8% of wild-type activity | Plasmodium falciparum |
D1359A | 3% of wild-type activity | Plasmodium falciparum |
G1382Y | no ODC activity | Plasmodium falciparum |
K868A | no ODC activity | Plasmodium falciparum |
K970A | no ODC activity | Plasmodium falciparum |
S73A | no AdometDC, i.e. ec4.1.1.50, activity, 90% of wild-type ODC activity | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
putrescine | - |
Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.041 | - |
L-ornithine | recombinant PfODC | Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | Plasmodium falciparum | first step in polyamine biosynthesis | putrescine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant PfODC | Plasmodium falciparum |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0388 | - |
recombinant PfODC | Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | - |
Plasmodium falciparum | putrescine + CO2 | - |
? | |
L-ornithine | first step in polyamine biosynthesis | Plasmodium falciparum | putrescine + CO2 | - |
? | |
additional information | bifunctional enzyme having both ODC and AdoMetDC, i.e. EC4.1.1.50, activity | Plasmodium falciparum | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PfODC/AdoMetDC | - |
Plasmodium falciparum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Plasmodium falciparum |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | 8.5 | - |
Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.068 | - |
putrescine | - |
Plasmodium falciparum |