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Literature summary for 4.1.1.19 extracted from

  • Jantaro, S.; Kidron, H.; Chesnel, D.; Incharoensakdi, A.; Mulo, P.; Salminen, T.; Maenpaa, P.
    Structural modeling and environmental regulation of arginine decarboxylase in Synechocystis sp. PCC 6803 (2006), Arch. Microbiol., 184, 397-406.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information profiles of the steady-state accumulation of Synechocystis ADC transcripts and ADC specific activities under various environmental conditions, e.g. photoheterotrophy, high temperature and high light conditions activate enzyme expression, overview Synechocystis sp.

Cloned(Commentary)

Cloned (Comment) Organism
profiles of the steady-state accumulation of Synechocystis ADC transcripts and ADC specific activities under various environmental conditions, overview Synechocystis sp.

Inhibitors

Inhibitors Comment Organism Structure
additional information profiles of the steady-state accumulation of Synechocystis ADC transcripts and ADC specific activities under various environmental conditions, e.g. darkness and cold reduce enzyme expression, overview Synechocystis sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine Synechocystis sp. key enzyme in the biosynthesis of polyamines, key enzyme in the biosynthesis of putrescine, plays a role in salt stress response, high temperature and glucose treatment causes an increase in the specific activity, the specific activity is reduced by iron deficiency agmatine + CO2
-
?
L-arginine Synechocystis sp. the first enzyme in the alternative route to putrescine in the polyamine biosynthesis pathway in bacteria and plants, posttranslational regulation involving a putative extra domain, modelling, overview agmatine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Synechocystis sp.
-
PCC 6803
-
Synechocystis sp.
-
strain PCC 6803, two genes encoding the enzyme
-
Synechocystis sp. P74576 isoform ADC1
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification two symmetric inter-subunit disulfide bonds seem to stabilize the dimeric structure of arginine decarboxylase Synechocystis sp.

Source Tissue

Source Tissue Comment Organism Textmining
additional information profiles of the steady-state accumulation of Synechocystis ADC transcripts and ADC specific activities under various environmental conditions Synechocystis sp.
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
profiles of the steady-state accumulation of Synechocystis ADC transcripts and ADC specific activities under various environmental conditions, overview Synechocystis sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine
-
Synechocystis sp. agmatine + CO2
-
?
L-arginine key enzyme in the biosynthesis of polyamines, key enzyme in the biosynthesis of putrescine, plays a role in salt stress response, high temperature and glucose treatment causes an increase in the specific activity, the specific activity is reduced by iron deficiency Synechocystis sp. agmatine + CO2
-
?
L-arginine the first enzyme in the alternative route to putrescine in the polyamine biosynthesis pathway in bacteria and plants, posttranslational regulation involving a putative extra domain, modelling, overview Synechocystis sp. agmatine + CO2
-
?
L-arginine effects of various types of short-term stresses on the transcript amount and specific activity of the enzyme, overview Synechocystis sp. agmatine + CO2
-
?

Subunits

Subunits Comment Organism
dimer stabilized by two inter-subunit disulfide bonds, structural modeling Synechocystis sp.
More Synechocystis ADCs have a putative extra domain, which might be involved in the posttranslational regulation of ADC activity, structural modeling, overview Synechocystis sp.

Synonyms

Synonyms Comment Organism
ADC
-
Synechocystis sp.

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate conserved binding site structure Synechocystis sp.
pyridoxal 5'-phosphate the pyridoxal 5'-phosphate-binding domain is linked to the C-terminal domain by the N-terminus Synechocystis sp.

Expression

Organism Comment Expression
Synechocystis sp. steady-state accumulation of arginine decarboxylase transcripts and its specific activity are unaffected by dark incubation additional information
Synechocystis sp. salt stress clearly results in an increased steady-state transcript accumulation even though the specific activity shows no apparent change up