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Literature summary for 4.1.1.19 extracted from

  • Zhu, M.Y.; Wang, W.P.; Huang, J.; Feng, Y.Z.; Regunathan, S.; Bissette, G.
    Repeated immobilization stress alters rat hippocampal and prefrontal cortical morphology in parallel with endogenous agmatine and arginine decarboxylase levels (2008), Neurochem. Int., 53, 346-354.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information ADC protein levels and endogenous agmatine levels are significantly increased in the prefrontal cortex, hippocampus, striatum and hypothalamus by immobilization stress. As one element of self-protection mechanisms in the brain, agmatine synthesis is triggered by repeated immobilization through activation of ADC expression, which in turn increases endogenous agmatine levels as an initial protective response to stress. Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine Rattus norvegicus rate-limiting enzyme in polyamine biosynthesis agmatine + CO2 agmatine is a neurotransmitter or neuromodulator in the brain, agmatine has neuroprotective effects in vitro and in vivo ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
 Rattus norvegicus
-
hypothalamus
-
 Rattus norvegicus
-
prefrontal cortex
-
 Rattus norvegicus
-
striatum
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine rate-limiting enzyme in polyamine biosynthesis Rattus norvegicus agmatine + CO2 agmatine is a neurotransmitter or neuromodulator in the brain, agmatine has neuroprotective effects in vitro and in vivo ?

Synonyms

Synonyms Comment Organism
ADC
-
 Rattus norvegicus
arginine decarboxylase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus