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Literature summary for 4.1.1.21 extracted from

  • Humble, R.W.; Mackenzie, G.; Shaw, G.
    Rapid purification of a bifunctional protein complex possessing phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) and phosphoribosylaminoimidazolesuccinocarboxamide synthetase (EC 6.3.2.6) activities (1991), Adv. Exp. Med. Biol., 7, 223-227.
    View publication on PubMed
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40500
-
 1 * 40500 + 1 * 56000, SDS-PAGE, two subunits associate in a 1:1 ratio Ovis aries
56000
-
 1 * 40500 + 1 * 56000, SDS-PAGE, two subunits associate in a 1:1 ratio Ovis aries
420000
-
 gel filtration Ovis aries

Organism

Organism UniProt Comment Textmining
Ovis aries
-
-
-

Purification (Commentary)

Purification (Comment) Organism
bifunctional protein complex possessing phosphoribosylaminoimidazole carboxylase, EC 4.1.1.21, and phosphoribosylaminoimidazolesuccinocarboxamide synthetase, EC 6.3.2.6, activities Ovis aries

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Ovis aries
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
42.75
-
-
 Ovis aries

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-(5-Phosphoribosyl)-5-aminoimidazole + CO2
-
 Ovis aries 1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate
-
 ?

Subunits

Subunits Comment Organism
? 1 * 40500 + 1 * 56000, SDS-PAGE, two subunits associate in a 1:1 ratio Ovis aries

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
22
-
 stable for several days Ovis aries

pH Stability

pH Stability pH Stability Maximum Comment Organism
6 8 stable Ovis aries