Activating Compound | Comment | Organism | Structure |
---|---|---|---|
gastrin | increase of steady-state levels of 6 HDC isoforms | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expression in COS-7 cells | Rattus norvegicus |
expression of cDNA in COS-7 cells | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-histidine | Rattus norvegicus | - |
histamine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | post-translational processing of 74000 Da HDC is required for activity, carboxyl-terminal processing generates an active 55000 Da isoform and additional isoforms with molecular weights higher than 55000 Da | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-histidine | - |
Rattus norvegicus | histamine + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | five HDC isoforms of 63000 Da, 54000 Da, 48000 Da, 40000 Da and 36000 Da, that derive from the 74000 Da full-length primary translation isoform | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
HDC | - |
Rattus norvegicus |