Literature summary for 4.1.1.25 extracted from

Facchini, P.J.; Huber-Allanach, K.L.; Tari, L.W.
Plant aromatic L-amino acid decarboxylases: evolution, biochemistry, regulation, and metabolic engineering applications (2000), Phytochemistry, 54, 121-138.

Application

Application	Comment	Organism
pharmacology	biosynthesis of pharmaceutically important monoterpenoid indole alkaloids	Hordeum vulgare
pharmacology	biosynthesis of pharmaceutically important monoterpenoid indole alkaloids	Petroselinum crispum
pharmacology	biosynthesis of pharmaceutically important monoterpenoid indole alkaloids	Syringa vulgaris
pharmacology	biosynthesis of pharmaceutically important monoterpenoid indole alkaloids	Sanguinaria canadensis
pharmacology	biosynthesis of pharmaceutically important monoterpenoid indole alkaloids	Thalictrum rugosum
pharmacology	biosynthesis of pharmaceutically important monoterpenoid indole alkaloids	Eschscholzia californica
pharmacology	biosynthesis of pharmaceutically important monoterpenoid indole alkaloids	Cytisus scoparius
pharmacology	biosynthesis of pharmaceutically important monoterpenoid indole alkaloids	Chondrodendron tomentosum
pharmacology	biosynthesis of pharmaceutically important monoterpenoid indole alkaloids	Petunia sp.
pharmacology	biosynthesis of pharmaceutically important monoterpenoid indole alkaloids	Arabidopsis thaliana
pharmacology	biosynthesis of pharmaceutically important monoterpenoid indole alkaloids	Papaver somniferum
pharmacology	biosynthesis of pharmaceutically important monoterpenoid indole alkaloids	Colchicum autumnale

Cloned(Commentary)

Cloned (Comment)	Organism
-	Hordeum vulgare
-	Petroselinum crispum
-	Syringa vulgaris
-	Sanguinaria canadensis
-	Thalictrum rugosum
-	Eschscholzia californica
-	Cytisus scoparius
-	Chondrodendron tomentosum
-	Petunia sp.
-	Arabidopsis thaliana
-	Papaver somniferum
-	Colchicum autumnale

Inhibitors

Inhibitors	Comment	Organism
L-2-aminoxy-3-phenylpropionate	-	Eschscholzia californica
L-2-aminoxy-3-phenylpropionate	-	Hordeum vulgare
L-2-aminoxy-3-phenylpropionate	-	Syringa vulgaris

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism
0.25	-	L-Dopa	no details of experimental conditions given	Thalictrum rugosum
0.27	-	L-tyrosine	no details of experimental conditions given	Thalictrum rugosum
1	-	L-tyrosine	-	Eschscholzia californica
1	-	L-tyrosine	-	Papaver somniferum
1	-	L-Dopa	-	Papaver somniferum
1.1	-	L-Dopa	-	Eschscholzia californica

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
112000	-	-	Thalictrum rugosum
112000	-	-	Eschscholzia californica

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
L-Tyrosine	Hordeum vulgare	-	Tyramine + CO2	-	?
L-Tyrosine	Petroselinum crispum	-	Tyramine + CO2	-	?
L-Tyrosine	Syringa vulgaris	-	Tyramine + CO2	-	?
L-Tyrosine	Sanguinaria canadensis	-	Tyramine + CO2	-	?
L-Tyrosine	Thalictrum rugosum	-	Tyramine + CO2	-	?
L-Tyrosine	Eschscholzia californica	-	Tyramine + CO2	-	?
L-Tyrosine	Chondrodendron tomentosum	-	Tyramine + CO2	-	?
L-Tyrosine	Petunia sp.	-	Tyramine + CO2	-	?
L-Tyrosine	Arabidopsis thaliana	-	Tyramine + CO2	-	?
L-Tyrosine	Papaver somniferum	-	Tyramine + CO2	-	?
L-Tyrosine	Colchicum autumnale	-	Tyramine + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	Q8RY79	-	-
Chondrodendron tomentosum	-	-	-
Colchicum autumnale	-	-	-
Cytisus scoparius	-	-	-
Eschscholzia californica	-	california poppy	-
Hordeum vulgare	-	-	-
Papaver somniferum	P54768	opium poppy	-
Petroselinum crispum	-	parsley	-
Petunia sp.	-	-	-
Sanguinaria canadensis	-	-	-
Syringa vulgaris	-	-	-
Thalictrum rugosum	-	meadow rue	-

Purification (Commentary)

Purification (Comment)	Organism
-	Thalictrum rugosum

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
2-fluoro-L-tyrosine	-	Eschscholzia californica	2-fluorotyramine + CO2	-	?
L-Dopa	-	Hordeum vulgare	dopamine + CO2	-	?
L-Dopa	-	Petroselinum crispum	dopamine + CO2	-	?
L-Dopa	-	Syringa vulgaris	dopamine + CO2	-	?
L-Dopa	-	Sanguinaria canadensis	dopamine + CO2	-	?
L-Dopa	-	Thalictrum rugosum	dopamine + CO2	-	?
L-Dopa	-	Eschscholzia californica	dopamine + CO2	-	?
L-Dopa	-	Cytisus scoparius	dopamine + CO2	-	?
L-Dopa	-	Chondrodendron tomentosum	dopamine + CO2	-	?
L-Dopa	-	Petunia sp.	dopamine + CO2	-	?
L-Dopa	-	Arabidopsis thaliana	dopamine + CO2	-	?
L-Dopa	-	Papaver somniferum	dopamine + CO2	-	?
L-Dopa	-	Colchicum autumnale	dopamine + CO2	-	?
L-Tyrosine	-	Hordeum vulgare	Tyramine + CO2	-	?
L-Tyrosine	-	Petroselinum crispum	Tyramine + CO2	-	?
L-Tyrosine	-	Syringa vulgaris	Tyramine + CO2	-	?
L-Tyrosine	-	Sanguinaria canadensis	Tyramine + CO2	-	?
L-Tyrosine	-	Thalictrum rugosum	Tyramine + CO2	-	?
L-Tyrosine	-	Eschscholzia californica	Tyramine + CO2	-	?
L-Tyrosine	-	Chondrodendron tomentosum	Tyramine + CO2	-	?
L-Tyrosine	-	Petunia sp.	Tyramine + CO2	-	?
L-Tyrosine	-	Arabidopsis thaliana	Tyramine + CO2	-	?
L-Tyrosine	-	Papaver somniferum	Tyramine + CO2	-	?
L-Tyrosine	-	Colchicum autumnale	Tyramine + CO2	-	?
additional information	exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan	Hordeum vulgare	?	-	?
additional information	exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan	Petroselinum crispum	?	-	?
additional information	exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan	Syringa vulgaris	?	-	?
additional information	exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan	Sanguinaria canadensis	?	-	?
additional information	exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan	Thalictrum rugosum	?	-	?
additional information	exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan	Eschscholzia californica	?	-	?
additional information	exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan	Cytisus scoparius	?	-	?
additional information	exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan	Chondrodendron tomentosum	?	-	?
additional information	exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan	Petunia sp.	?	-	?
additional information	exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan	Arabidopsis thaliana	?	-	?
additional information	exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan	Papaver somniferum	?	-	?
additional information	exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan	Colchicum autumnale	?	-	?

Subunits

Subunits	Comment	Organism
homodimer	-	Thalictrum rugosum
homodimer	-	Eschscholzia californica

Synonyms

Synonyms	Comment	Organism
AADC	-	Hordeum vulgare
AADC	-	Petroselinum crispum
AADC	-	Syringa vulgaris
AADC	-	Sanguinaria canadensis
AADC	-	Thalictrum rugosum
AADC	-	Eschscholzia californica
AADC	-	Cytisus scoparius
AADC	-	Chondrodendron tomentosum
AADC	-	Petunia sp.
AADC	-	Arabidopsis thaliana
AADC	-	Papaver somniferum
AADC	-	Colchicum autumnale
AtTYDC	-	Arabidopsis thaliana
L-amino acid decarboxylase	-	Hordeum vulgare
L-amino acid decarboxylase	-	Petroselinum crispum
L-amino acid decarboxylase	-	Syringa vulgaris
L-amino acid decarboxylase	-	Sanguinaria canadensis
L-amino acid decarboxylase	-	Thalictrum rugosum
L-amino acid decarboxylase	-	Eschscholzia californica
L-amino acid decarboxylase	-	Cytisus scoparius
L-amino acid decarboxylase	-	Chondrodendron tomentosum
L-amino acid decarboxylase	-	Petunia sp.
L-amino acid decarboxylase	-	Arabidopsis thaliana
L-amino acid decarboxylase	-	Papaver somniferum
L-amino acid decarboxylase	-	Colchicum autumnale
PcTYDC2	-	Petroselinum crispum
PsTYDC1	-	Papaver somniferum
PsTYDC2	-	Papaver somniferum
TYDC	-	Hordeum vulgare
TYDC	-	Petroselinum crispum
TYDC	-	Syringa vulgaris
TYDC	-	Sanguinaria canadensis
TYDC	-	Thalictrum rugosum
TYDC	-	Eschscholzia californica
TYDC	-	Cytisus scoparius
TYDC	-	Chondrodendron tomentosum
TYDC	-	Petunia sp.
TYDC	-	Arabidopsis thaliana
TYDC	-	Papaver somniferum
TYDC	-	Colchicum autumnale
tyrosine decarboxylase-2	-	Petroselinum crispum
tyrosine/Dopa decarboxylase-1	-	Papaver somniferum
tyrosine/Dopa decarboxylase-2	-	Papaver somniferum

Cofactor

Cofactor	Comment	Organism
pyridoxal 5'-phosphate	-	Hordeum vulgare
pyridoxal 5'-phosphate	-	Petroselinum crispum
pyridoxal 5'-phosphate	-	Syringa vulgaris
pyridoxal 5'-phosphate	-	Sanguinaria canadensis
pyridoxal 5'-phosphate	-	Thalictrum rugosum
pyridoxal 5'-phosphate	-	Eschscholzia californica
pyridoxal 5'-phosphate	-	Cytisus scoparius
pyridoxal 5'-phosphate	-	Chondrodendron tomentosum
pyridoxal 5'-phosphate	-	Petunia sp.
pyridoxal 5'-phosphate	-	Arabidopsis thaliana
pyridoxal 5'-phosphate	-	Papaver somniferum
pyridoxal 5'-phosphate	-	Colchicum autumnale

pI Value

Organism	Comment	pI Value Maximum	pI Value
Eschscholzia californica	-	-	5.2