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Literature summary for 4.1.1.28 extracted from

  • Bertoldi, M.; Borri Voltattorni, C.
    Reaction and substrate specificity of recombinant pig kidney DOPA decarboxylase under aerobic and anaerobic conditions (2003), Biochim. Biophys. Acta, 1647, 42-47.
    View publication on PubMed
Search for more literature for 4.1.1.28

Application

Application Comment Organism
medicine development of dopamine treatment ainst Parkinson's disease, drug target for treatment of neurodgenerative diseases Sus scrofa

Cloned(Commentary)

Cloned (Comment) Organism
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan Sus scrofa
-
 tryptamine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
 pig
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-hydroxy-L-tryptophan
-
 Sus scrofa serotonin + CO2
-
 ?
5-hydroxytryptamine + O2 side reaction, decarboxylation-dependent transamination Sus scrofa 5-hydroxyindolacetaldehyde + NH3
-
 ?
alpha-methyl-dopamine + O2 side reaction, decarboxylation-dependent transamination Sus scrofa 3,4-dihydroxyphenylacetone + NH3
-
 ?
alpha-methyl-L-Dopa
-
 Sus scrofa alpha-methyl-dopamine + CO2
-
 ?
dopamine + O2
-
 Sus scrofa 3,4-dihydroxyphenylacetaldehyde + NH3
-
 ?
L-Dopa
-
 Sus scrofa dopamine + CO2
-
 ?
L-tryptophan
-
 Sus scrofa tryptamine + CO2
-
 ?
additional information exhibits half-transaminase activity toward D-aromatic amino acids and oxidative deaminase activity toward aromatic amines Sus scrofa ?
-
 ?

Subunits

Subunits Comment Organism
homodimer
-
 Sus scrofa

Synonyms

Synonyms Comment Organism
DDC
-
 Sus scrofa
DOPA decarboxylase
-
 Sus scrofa

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Sus scrofa