Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | DDC is overexpressed, at the mRNA level, in the specimens from prostate cancer patients, in comparison to those from benign prostate hyperplasia patients. High expression levels of DDC are found more frequently in high Gleason's score tumors as well as in advanced stage patients. | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | potential of DDC expression, at the mRNA level, as a novel biomarker in prostate cancer | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-Hydroxytryptophan | Homo sapiens | - |
Serotonin + CO2 | neurotransmitter | ? | |
L-Dopa | Homo sapiens | - |
dopamine + CO2 | - |
? | |
additional information | Homo sapiens | L-dopa decarboxylase is a pyridoxal 5'-phosphate-dependent enzyme involved in many malignancies | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PC-3 cell | prostate cancer | Homo sapiens | - |
prostate cancer cell line | LNCaP cell | Homo sapiens | - |
prostate gland | total RNA is isolated from tissue specimens from benign prostate hyperplasia and prostate cancer patients | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-Hydroxytryptophan | - |
Homo sapiens | Serotonin + CO2 | neurotransmitter | ? | |
L-Dopa | - |
Homo sapiens | dopamine + CO2 | - |
? | |
additional information | L-dopa decarboxylase is a pyridoxal 5'-phosphate-dependent enzyme involved in many malignancies | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
AADC | - |
Homo sapiens |
Aromatic L-amino acid decarboxylase | - |
Homo sapiens |
DDC | - |
Homo sapiens |
L-DOPA decarboxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |