Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Benserazide | competitive inhibitor of L-Dopa, but a non-competitive inhibitor of 5-hydroxytryptophan | Homo sapiens | |
carbidopa | - |
Homo sapiens | |
NSD-1015 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-Hydroxytryptophan | Homo sapiens | - |
Serotonin + CO2 | - |
? | |
L-Dopa | Homo sapiens | - |
dopamine + CO2 | - |
? | |
L-phenylalanine | Homo sapiens | - |
2-phenylethylamine + CO2 | - |
? | |
L-Trp | Homo sapiens | - |
Tryptamine + CO2 | - |
? | |
m-tyrosine | Homo sapiens | - |
m-tyramine + CO2 | - |
? | |
p-tyrosine | Homo sapiens | - |
p-tyramine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
striatum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-Hydroxytryptophan | - |
Homo sapiens | Serotonin + CO2 | - |
? | |
L-Dopa | - |
Homo sapiens | dopamine + CO2 | - |
? | |
L-phenylalanine | - |
Homo sapiens | 2-phenylethylamine + CO2 | - |
? | |
L-Trp | - |
Homo sapiens | Tryptamine + CO2 | - |
? | |
m-tyrosine | - |
Homo sapiens | m-tyramine + CO2 | - |
? | |
p-tyrosine | - |
Homo sapiens | p-tyramine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AADC | - |
Homo sapiens |
DOPA decarboxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | the essential cofactor stabilizes and enhances enzymatic activity | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | AADC deficiency is an autosomal recessive disorder caused by mutations in the AADC gene leading to severely reduced AADC activity. The condition presents early in life and is characterized by axial hypotonia, hypokinesia, choreoathetosis, developmentaldelay and episodes of dystonia, limb hypertonia and oculogyric crises | Homo sapiens |