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Literature summary for 4.1.1.36 extracted from

  • Kupke, T.
    Molecular characterization of the 4'-phosphopantothenoylcysteine decarboxylase domain of bacterial Dfp flavoproteins (2001), J. Biol. Chem., 276, 27597-27604.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
5'partof the dfp gene is cloned and overexpressed Escherichia coli

Protein Variants

Protein Variants Comment Organism
A17D site-directed mutagenesis Escherichia coli
G14S site-directed mutagenesis Escherichia coli
G15A site-directed mutagenesis Escherichia coli
I16L site-directed mutagenesis Escherichia coli
K20N site-directed mutagenesis Escherichia coli
K20Q site-directed mutagenesis Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20100
-
12 * 20100, homododecamer, SDS-PAGE Escherichia coli
270000
-
CoAC domain, gel filtration Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-[(R)-4'-phosphopantothenoyl]-L-cysteine Escherichia coli key step in coenzyme A biosynthesis pantotheine 4'-phosphate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
Escherichia coli pantotheine 4'-phosphate + CO2
-
?
N-[(R)-4'-phosphopantothenoyl]-L-cysteine key step in coenzyme A biosynthesis Escherichia coli pantotheine 4'-phosphate + CO2
-
?

Subunits

Subunits Comment Organism
dodecamer 12 * 20100, homododecamer, SDS-PAGE Escherichia coli

Synonyms

Synonyms Comment Organism
dfp flavoprotein
-
Escherichia coli
PPC decarboxylase
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
flavin flavin-containing Cys decarboxylase Escherichia coli