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Literature summary for 4.1.1.37 extracted from
- Uroporphyrinogen decarboxylase. Purification, properties, and inhibition by polychlorinated biphenyl isomers (1983), J. Biol. Chem., 258, 4285-4292.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,3,2',3'-Tetrachlorobiphenyl | - |
Gallus gallus |  |
| 2,3,4,2',3',4'-Hexachlorobiphenyl | - |
Gallus gallus | |
| 2,4,2',4'-Tetrachlorobiphenyl | - |
Gallus gallus | |
| 2,4,6,2',4',6'-Hexachlorobiphenyl | - |
Gallus gallus | |
| 2,5,2',5'-Tetrachlorobiphenyl | - |
Gallus gallus | |
| 2,6,2',6'-Tetrachlorobiphenyl | - |
Gallus gallus | |
| 3,4,3',4'-Tetrachlorobiphenyl | - |
Gallus gallus | |
| 3,4,5,3',4',5'-Hexachlorobiphenyl | - |
Gallus gallus | |
| 3,5,3',5'-Tetrachlorobiphenyl | - |
Gallus gallus | |
| 5,5'-dithiobis(2-nitrobenzoate) | - |
Gallus gallus | |
| acetone | - |
Gallus gallus | |
| diethyldicarbonate | - |
Gallus gallus | |
| ethanol | - |
Gallus gallus | |
| Isopropyl alcohol | - |
Gallus gallus | |
| methanol | - |
Gallus gallus | |
| NEM | - |
Gallus gallus | |
| PCMB | - |
Gallus gallus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 39700 | - |
2 * 39700, SDS-PAGE | Gallus gallus |
| 79000 | - |
gel filtration | Gallus gallus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Gallus gallus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0237 | - |
- |
Gallus gallus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| uroporphyrinogen I | - |
Gallus gallus | coproporphyrinogen I + 4 CO2 | - |
? | |
| Uroporphyrinogen III | - |
Gallus gallus | Coproporphyrinogen III + 4 CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 39700, SDS-PAGE | Gallus gallus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
uroporphyrinogen III | Gallus gallus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 7.4 | pH 6.0: about 55% of maximal activity, pH 7.4: about 50% of maximal activity, uroporphyrinogen III | Gallus gallus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | contains no pyridoxal phosphate, flavin and heme | Gallus gallus |
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