Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Uroporphyrinogen III | Rattus norvegicus | the enzyme functions in the heme biosynthetic pathway, catalyzing the decarboxylation of the four acetate groups of uroporphyrinogen to form coproporphyrinogen | Coproporphyrinogen III + 4 CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
normal animals and animals with hexachlorobenzene-induced porphyria | - |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Uroporphyrinogen III | the enzyme functions in the heme biosynthetic pathway, catalyzing the decarboxylation of the four acetate groups of uroporphyrinogen to form coproporphyrinogen | Rattus norvegicus | Coproporphyrinogen III + 4 CO2 | - |
? | |
Uroporphyrinogen III | with the enzyme from normal animals, uroporphyrinogen and pentacarboxy-porphyrinogen react at the same active site, i.e. the first and fourth decarboxylation occur at the same site. In animals with hexachlorobenzene-induced porphyria the two reactions occur at functionally different sites, but with cross-inhibition. This suggests that hexachlorobenzene causes the two active sites to become nonequivalent and functionally different | Rattus norvegicus | Coproporphyrinogen III + 4 CO2 | - |
? |