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Literature summary for 4.1.1.45 extracted from
- Purification and properties of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), key enzyme of niacin synthesis from tryptophan, from hog kidney (1996), J. Nutr. Sci. Vitaminol., 42, 173-183.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diethyldicarbonate | - |
Sus scrofa |  |
| iodoacetamide | - |
Sus scrofa | |
| Monoiodoacetic acid | - |
Sus scrofa | |
| N-Acetylimidazole | - |
Sus scrofa | |
| NEM | - |
Sus scrofa | |
| PCMB | - |
Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0161 | - |
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | - |
Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 41000 | - |
1 * 41000, SDS-PAGE | Sus scrofa |
| 58000 | - |
gel filtration | Sus scrofa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | Sus scrofa | key enzyme of niacin synthesis from Trp | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
hog | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 3.789 | - |
- |
Sus scrofa |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 50 mM potassium phosphate buffer, pH 7.0, 0.14 M KCl, 5 mM 2-mercaptoethanol, 1 mM dithiothreitol, 1 mM EDTA, 20% glycerol, stable for at least 1 month | Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | - |
Sus scrofa | 2-aminomuconate semialdehyde + CO2 | - |
? | |
| 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | key enzyme of niacin synthesis from Trp | Sus scrofa | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 41000, SDS-PAGE | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Sus scrofa |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9 | pH 6: about 40% of maximal activity, pH 9.0: about 35% of maximal activity | Sus scrofa |
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